重症肌无力与CTLA-4基因多态性的Meta分析  

Association between CTLA-4 gene polymorphism and mysathenia gravis susceptibility: a Meta-analysis

作　　者：汪煜[1] 陈银河[2] 王文静[1] 刘晓敏[3] 

机构地区：[1]安徽医科大学附属省立医院神经内科,合肥230001 [2]安徽医科大学附属阜阳医院骨科,阜阳236000 [3]安徽省肿瘤医院(安徽省立医院西区)急诊内科,合肥230031

出　　处：《安徽医科大学学报》2017年第4期508-514,共7页Acta Universitatis Medicinalis Anhui

基　　金：安徽省卫生厅医学科研课题(编号:13zc032)

摘　　要：目的探讨细胞毒性T淋巴细胞相关抗原-4(CTLA-4)基因多位点单核苷酸多态性(SNP)与重症肌无力(MG)易感性的关联情况。方法通过中国生物医学文献数据库、中国期刊网全文数据库、万方、维普、PubMed、Cochrane Library、OvidSP、Wiley Online Library、EBSCO、Elsevier Science Direct、Springer Link数据库检索CTLA-4基因与MG相关的病例对照研究,利用Rev Man 5.3软件计算其基因型和等位基因与MG的关联性。结果共纳入10篇文献,将MG分为胸腺瘤型MG(TAMG)、胸腺增生型MG(THMG)、自身免疫性MG(AIMG)。Meta分析显示携有CTLA-4基因rs231775 G等位基因的人群罹患MG的风险增高(OR=1.55,95%CI:1.13~2.12,P=0.006)、罹患AIMG的风险增高(OR=1.39,95%CI:1.09~1.77,P=0.007),携有rs733618 CC基因型的人群罹患AIMG的风险增高(OR=3.28,95%CI:1.89~5.70,P<0.001),携有rs733618 C等位基因的人群罹患AIMG的风险增高(OR=1.76,95%CI:1.30~2.37,P<0.001)。结论 CTLA-4基因rs231775 G等位基因、rs733618CC基因型和C等位基因与AIMG易感性之间有关联性。Objective To explore the association between CTLA-4 gene polymorphism and susceptibility to mysathenia gravis（MG）. Methods The case-control studies from Chinese biomedical database,Chinese national knowledge infrastructure,Wanfang,Weipu,PubMed,Cochrane Library,OvidSP,Wiley Online Library,EBSCO,Elsevier Science Direct,Springer Link databases for the association CTLA-4 gene polymorphism with MG. The association strength were assessed by Rev Man 5. 3 software. Results Ten references were enrolled in total. MG was divided into thymoma-associated MG（TAMG）,thymic hyperplasia MG（THMG） and autoimmune MG（AIMG）.The Meta analysis showed that carriers of rs231775 allele G have higher risk of MG（OR = 1. 55,95% CI： 1. 13 ~2. 12,P = 0. 006）,and higher risk of AIMG（OR = 1. 39,95% CI： 1. 09 ~ 1. 77,P = 0. 007） by subgroup analysis.Carriers of rs733618 genotype CC（OR = 3. 28,95% CI： 1. 89 ~ 5. 70,P〈0. 001） and allele C（OR = 1. 76,95%CI： 1. 30 ~ 2. 37,P〈0. 001） have higher risk of AIMG by subgroup analysis. Conclusion The meta analysis reveales that rs231775 allele G,rs733618 genotype CC and allele C of CTLA-4 gene is associated with the susceptibility to MG.

关 键 词：重症肌无力 细胞毒性T淋巴细胞相关抗原 多态性 单核苷酸 META分析 

分 类 号：R746.1[医药卫生—神经病学与精神病学] R342.43[医药卫生—临床医学]