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出 处:《中国肿瘤临床与康复》2017年第3期309-312,共4页Chinese Journal of Clinical Oncology and Rehabilitation
摘 要:目的探讨三维适形放疗联合替吉奥治疗局部晚期食管癌的疗效及毒副作用。方法选取2013年10月至2015年12月间山东省菏泽市立医院收治的80例局部晚期食管癌患者,采用信封法随机分为观察组和对照组,每组40例,所有患者均给予适形放疗。同时,观察组患者放疗第一天口服替吉奥胶囊40mg,每天两次,d1~14,共2个周期,对照组在放疗第一天行顺铂和5氟尿嘧啶(DF方案)化疗。结果观察组患者完成同期放化疗率为95.0%,对照组患者为87.5%。观察组患者的近期有效率为75.0%,对照组患者70.0%,差异无统计学意义(均P>0.05)。观察组患者3~4级骨髓抑制和恶心呕吐的发生率较对照组低,差异有统计学意义(P<0.05)。观察组患者1年和2年生存率为74.1%和54.8%对照组患者为73.3%和53.5%,差异无统计学意义(χ~2=3.91,P>0.05;χ~2=3.98,P>0.05)。结论适形放疗联合替吉奥同期化疗疗效较好,且患者依从性较好,不良反应较低,远期疗效好,值得临床推广应用。Objective To investigate the efficacy and side effects of three-dimensional conformal radiotherapy with tegafur for locally advanced esophageal cancer. Methods Eighty patients with locally advanced esophageal cancer who treated at Heze Municiple Hospital from October 2013 to December 2015 were selected. Patients were randomly divided into an observation group and a control group, with 40 patients in each group. All the patients received conformal radiotherapy. Patients in the observation group took tegafur capsule 40 mg twice daily on the first day of conformal radiotherapy for 2 cycles and patients in the control group received cisplatin and 5-tluorouracil on the first day of radiotherapy ( DF chemotherapy). Results Ninety-five perctent patients in the experimental group completed chemotherapy and 87. 5% patients in the control group completed chemotherapy. The short-term efficiency rate was 75.0% for the observation group and 70. 0% for the control group significant ( all P 〉 0. 05 ). The incidence of class 3 - 4 myelosuppression, nausea and vomiting was lower in the observation group than in the control group (P 〈 0. 05 ) ; The 1-and 2- year survival rate was 74. 1% and 54. 8% for the the observation group and 73.3% and 53.5% for the control group respectively( X^2 =3.91,P〉0. 05;z2 =3.98,P〉0.05). Conclusion Conformal radiotherapy combined with tegafur chemotherapy has a good efficacy and compliance with low toxicity. It is worthy of clinical application.
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