CyclinD1及CDK4在软骨肉瘤诊断中的应用  

Expression and clinical significance of CyclinD1 and CDK4 in chondrosarcoma

作　　者：王克猛[1] 魏世平[2] 牛长磊 王海燕 牛军强[1] 孟庆聚 

机构地区：[1]邢台医学高等专科学校第一附属医院骨科,河北省邢台市054000 [2]邢台医学高等专科学校

出　　处：《河北医药》2017年第7期985-987,共3页Hebei Medical Journal

摘　　要：目的观察Cyclin D1及CDK4蛋白在软骨肉瘤中的阳性表达状态,探讨Cyclin D1及CDK4蛋白在软骨肉瘤发生发展中的机制。方法以SP法检测肿瘤组织中Cyclin D1及CDK4蛋白表达的情况。结果软骨肉瘤组织中Cyclin D1、CDK4同时高表达,两者呈正相关关系(P<0.05)。结论 Cyclin D1及CDK4蛋白均呈高表达,在软骨肉瘤的发生发展中起互相协同,使肿瘤细胞的生长优势增强,对肿瘤的发生发展中发挥重要作用。Objective To observe the expression of Cyclin D1 and CDK4 proteins in chondrosarcoma,and to explore their action mechanism in pathogebesis and development of chondrosarcoma.Methods The expression levels of Cyclin D1 and CDK4 protein were detected by immunohistochemistry（SP）.Results The high-expression of Cyclin D1 and CDK4 was found in chondrosarcoma tissues,moreover,the expression levels of Cyclin D1 were positively correlated to those of CDK4（P〈0.05）.Conclusion The high-expressin of Cyclin D1 and CDK4 exists in chondrosarcoma tissues,which plays an important role in pathogenesis and development of chondrosarcoma.

关 键 词：软骨肉瘤 CYCLIND1蛋白 CDK4蛋白 免疫组织化学 

分 类 号：R738.3[医药卫生—肿瘤]