晚期结直肠癌患者化疗前后细胞免疫功能变化研究  

Changes of Cellular Immune Function in Patients with Advanced Colorectal Cancer before and after Chemotherapy

作　　者：原春玲[1] 梁嵘[1] 林燕[1] 黎倩[1] 张玉梅[1] 李永强[1] 

机构地区：[1]广西医科大学附属肿瘤医院化疗一科,广西南宁市530021

出　　处：《实用心脑肺血管病杂志》2016年第B12期132-134,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：广西卫生和计划生育委员会自筹经费课题(Z2015717)--恩在适在奥沙利铂神经毒性防治中的应用研究

摘　　要：目的探讨晚期结直肠癌患者化疗前后细胞免疫功能的变化及临床意义。方法选取2014年5月—2015年5月广西医科大学附属肿瘤医院就诊的晚期结直肠癌患者58例为病例组,另选取健康志愿者30例为对照组。病例组患者接受FOLFIRI方案或m FOLFOX6方案化疗,4周期后评估疗效。分别于化疗前1~2d,化疗第1周期后第1、2周以及第4周期化疗结束后,检测T淋巴细胞亚群。结果病例组化疗前CD＋3T细胞百分比、CD＋4T细胞百分比、CD＋4/CD＋8比值低于对照组,病例组化疗后1周CD＋3T细胞百分比、CD＋4T细胞百分比、CD＋4/CD＋8比值低于化疗前（P〈0.05）。病例组化疗后2周CD＋3T细胞百分比、CD＋4T细胞百分比、CD＋4/CD＋8比值与化疗前比较,差异无统计学意义（P〉0.05）。化疗有效患者CD＋3T细胞百分比、CD＋4T细胞百分比、CD＋4/CD＋8比值高于化疗无效患者（P〈0.05）。结论有效的化疗有助于改善晚期结直肠癌患者的细胞免疫功能。Objective To investigate the changes and clinical significance of cellular immune function in patients with advanced colorectal cancer before and after chemotherapy. Methods 58 patients with advanced colorectal cancer who were admitted to the Affiliated Tumor Hospital of Guangxi Medical University from May 2014 to May 2015 were selected as the case group,and 30 healthy volunteers were selected as control group. Patients in the case group received FOLFIRI regimen or m FOLFOX6 regimen chemotherapy,and the efficacy were assessed after 4 cycles. The T lymphocyte subsets were detected at 1-2d before chemotherapy,first and second week after first cycle chemotherapy,and after fourth chemotherapy. Results The percentage of CD＋3T cells,the percentage of CD＋4T cells and the ratio of CD＋4/CD＋8in the case group before chemotherapy were lower than those in the control group,and the percentage of CD＋3T cells,the percentage of CD＋4T cells and the ratio of CD＋4/CD＋8were lower in the one week after chemotherapy than those before chemotherapy（ P 〈 0. 05）. There was no significant difference in the percentage of CD＋3T cells,the percentage of CD＋4T cells and the ratio of CD＋4/CD＋8between the patients before and after chemotherapy（ P 〉 0. 05）. The percentage of CD＋3T cells,the percentage of CD＋4T cells,and the ratio of CD＋4/CD＋8in patients with effective chemotherapy were higher than those in patients with ineffective chemotherapy（ P 〈 0. 05）. Conclusion Effective chemotherapy can help the patients with advanced colorectal cancer improving cellular immune function.

关 键 词：晚期结直肠癌 化疗 细胞免疫 T细胞亚群 

分 类 号：R735.3[医药卫生—肿瘤]