脂肪因子趋化素的相关研究进展  

The research progress of adipokine chemerin

作　　者：李悦[1] 徐丽梅[1] 

机构地区：[1]中国人民解放军空军总医院,北京100089

出　　处：《安徽医药》2017年第2期215-220,共6页Anhui Medical and Pharmaceutical Journal

摘　　要：趋化素(chemerin)是一种主要由白色脂肪组织分泌的蛋白,有促进免疫细胞向炎性部位趋化的功能,其通过与受体结合发挥生物效应。越来越多研究结果表明,chemerin能调节机体功能,影响代谢,并参与多种临床疾病的发生及发展,如炎性性疾病、代谢综合征、肿瘤、多囊卵巢综合征等。由于其参与机制尚不明确,且牵涉广泛,近年来在医学领域引起了较多的关注,越来越多学者致力于chemerin相关疾病及机制的探究,目前已经有许多研究表明其有可能成为治疗相应疾病的新靶点。Chemeirn is a kind of proteins mainly secreted from white adipose tissues （WAT） ,which recognized function is promoting immune cells to inflammatory site. The functions have been attributed to activation of the G protein-coupled receptor. Growing evidences show that this protein plays an important role in regulating body function, affecting metabolism, and participating in development of many diseases such as inflammatory diseases,metabolic syndrome （MetS） ,cancer,polycystic ovary syndrome and so on. However,the precise role of chemerin in these disorders remains unclear which attracts much scholarly attention in medical field in recent years. More and more scholars devote to the exploration of diseases correlation with chemerin and the mechanism. To date, some findings have featured its role in therapeutics which indicate that it may become a new therapeutic target of its related diseases.

关 键 词：趋化素 脂肪因子 代谢综合征 炎性 综述 

分 类 号：R363[医药卫生—病理学]