肝癌组织中肾上腺髓质激素的表达及与微血管密度的关系  

Expression of ADM in human liver carcinoma and its relationship with the density of micro vessels

作　　者：姚杨[1] 徐锐[1] 芦江[2] 苏杰[1] 叶芸[1] 

机构地区：[1]西安医学院附属医院中心实验室,西安710077 [2]西安医学院

出　　处：《海军医学杂志》2017年第2期119-121,148,共4页Journal of Navy Medicine

基　　金：西安市科技计划项目(SF1418(6));西安医学院科研基金资助项目(12FZ15);西安医学院大学生项目(11DXS01)

摘　　要：目的研究肾上腺髓质激素(ADM)在肝癌组织中的表达及其与肿瘤血管生成的关系。方法采用免疫组化法检测26例正常肝组织及58例肝癌组织中ADM表达,同时计数CD105标记的微血管密度(MVD),探讨ADM与MVD及临床病理特征之间的关系。结果肝癌组织ADM蛋白表达明显高于正常肝组织(P<0.01),肝癌组织中MVD明显高于正常肝组织(P<0.01)。两者的表达与患者年龄、病理类型无明显关系(P>0.05),而与肿瘤分化程度及TNM分级有一定关系(P<0.05)。结论肝癌组织中ADM的高含量,其与肿瘤血管生成有关,在肝癌发生发展过程中起重要作用,可作称为肝癌病变生物学行为的重要指标。Objective To investigate the expression of ADM in human liver carcinoma and its relationship with tumor angio-genesis. Methods The expression level of ADM was detected in 26 cases of normal liver tissues and the level of ADM in 58 cases ofliver carcinoma by immunohistochemical method. At the same time, the number of CD105-labelled micro vessel density （MVD） was counted, so as to investigate the relationship between ADM, MVD and their clinical pathological features. Results The expression lev-els of ADM and MVD in liver carcinoma were significantly higher than those in normal tissues （ P 〈 0. 01） . MVD in liver carcinoma was obviously higher than that of the normal liver（ P 〈 0. 01） . Their expression levels were not clearly correlated with the patient age and the pathological type （P 〈 0. 01 ） , while tumor differentiation was correlated with the degrading of TNM to some extent （ P 〈0. 05 ）. Conclusion The high expression of ADM in liver carcinoma was positively correlated with the formation of tumor vessels, which played a certain role in the occurrence and development of liver carcinoma, and might be important biological indicator of liver carcinoma.

关 键 词：乙肝相关性肝癌 肾上腺髓质激素 CD105 

分 类 号：R735.7[医药卫生—肿瘤]