上转换纳米材料在光动力疗法中的研究进展  

Progress in the research of upconversion nanomaterials in photodynamic therapy

作　　者：王玉凤[1] 李隆敏[1] 许桐瑛 白玉贤[1] 谢蕊[1] 杨飘萍[2] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院消化内科,黑龙江哈尔滨150081 [2]哈尔滨工程大学材料科学与化学工程学院,黑龙江哈尔滨150001

出　　处：《现代肿瘤医学》2017年第9期1489-1492,共4页Journal of Modern Oncology

基　　金：国家自然科学基金青年科学基金项目(编号:81401540);中国博士后科学基金(编号:2016M601420);哈尔滨医科大学附属肿瘤医院青年精英培养基金(编号:JY2015-02);于维汉院士杰出青年培养基金

摘　　要：光动力疗法(photodynamic therapy,PDT)是一种新型的肿瘤治疗方法,它与传统的手术治疗、放疗、化疗和免疫治疗等方法相比具有选择性高、创伤小和不良反应小等优点。随着对PDT的深入研究,研究人员发现传统的光敏剂水溶性差,且激发光的能量低,这些缺陷限制了PDT的发展。而近年来纳米技术和纳米材料的发展为研究人员带来了希望,上转换纳米材料(upconversion nanomaterials,UCNs)独特的性质可以克服传统光敏剂的缺点,为PDT带来新的进展。本综述主要集中于UCNs在PDT中的研究进展,并对其在PDT领域的未来发展趋势进行展望。Photodynamic therapy（PDT）is a new type of tumor therapy,compared with traditional surgical treatment,radiotherapy and chemotherapy which has the advantages of high selectivity,less trauma and side effects.With the deep study of PDT,the researchers found that water solubility of traditional photosensitzer is poor,and its energy of exciting light is low.These defects limited the development of PDT.In recent years,the development of nanotechnology and nanomaterials give new hope for the researchers.The unique properties of upconversion nanomaterials（UCNs）can overcome the shortcoming of the traditional photosensitizer and bring new progress for PDT.This review mainly focuses on the research progress of UCNs in PDT,and the development trend in the field of PDT in the future.

关 键 词：上转换纳米材料 光动力疗法 肿瘤 

分 类 号：R730.5[医药卫生—肿瘤]