低剂量沙利度胺对老年RAU患者外周血淋巴细胞亚群的影响  

Effects of Low Dose Thalidomide on Subsets of Peripheral Lymphocytes in Elderly Patients with Recurrent Aphthous Ulcer

作　　者：罗志晓[1] 艾俊[1] 柴红波[1] 陈明月[1] 冷卫东[1] 

机构地区：[1]十堰市太和医院.湖北医药学院附属医院口腔医学中心,湖北十堰442000

出　　处：《湖北医药学院学报》2017年第1期60-63,共4页Journal of Hubei University of Medicine

摘　　要：目的:观察沙利度胺对老年RAU患者外周血淋巴细胞亚群的影响及临床疗效。方法:应用小剂量沙利度胺治疗52例轻型RAU老年患者,自身对照观察疗效;同时测定治疗前后外周血淋巴细胞亚群,并与健康志愿者比较。结果:与健康对照组相比,老年RAU患者CD4+T淋巴细胞数目减少(P<0.05),淋巴细胞亚群比例失调,经小剂量沙利度胺治疗后,淋巴细胞亚群比例异常改善,同时患者溃疡间歇期明显延长、溃疡持续时间明显缩短、溃疡数目明显减少(P<0.05)。结论:老年RAU患者外周血CD4+T淋巴细胞减少,淋巴亚群比例异常,小剂量沙利度胺具有调节淋巴细胞亚群比例异常作用,能延长溃疡间歇期,减少溃疡发作,临床疗效满意。Objective To Observe the clinical efficacy of thalidomide in the treatment of elderly Recurrent Aphthous Ulcers（RAU） and its impact on subsets of lymphocytes in the peripheral circulation. Methods Thalidomide with dose of 12.5~25mg was administered for 52 elderly patients with early phase of RAU per day. The clinical effect was measured by comparing the remission time and the number of ulcers pre-and post-intervention. Meanwhile,the total number of peripheral lymphocytes and the ratio of CD4＋T cells to CD8＋T cells were measured before and after the intervention. The control group consisted of health volunteers. Results Compared with the control group,there was a significant decrease of CD4＋T cells（P〈0.05） and a significant increase of CD8＋T cells（P〈0.05） in the patients with early phase of RAU before treatment. The ratio of the two subsets was also abnormal. After the intervention,the ratio of the lymphocyte subsets was improved. Meanwhile,there was a significant increase in the remission time of the ulcers in the patient group（P〈0.05） and the number of ulcers was significantly reduced（P〈0.05）. Conclusion The ratio of the peripheral lymphocyte subsets is abnormal in elderly patients with the early phase of RAU. Thalidomide has a significant effect in correcting the abnormal ratio of CD4＋ T cells to CD8＋ T cells. It can also increase the remission time of ulcers and reduce the frequency of ulcer breakouts. The clinical efficacy has been satisfactory.

关 键 词：老年RAU 沙利度胺 淋巴细胞亚群 疗效 

分 类 号：R781.5[医药卫生—口腔医学]