普拉克索联合卡左双多巴缓释片治疗中晚期帕金森患者运动障碍疗效观察  

The clinical effect observation of pramipexole combined with card left duobarb sustained release tablets in middle-late of parkinson's patients with movement disorders

作　　者：魏建刚[1] 张倩[1] 杨建波[1] 孙薇[1] 徐金凤[1] 吕书勤[2] 

机构地区：[1]新疆医科大学附属中医医院神经内科,乌鲁木齐市830000 [2]新疆医科大学附属中医医院VIP科,乌鲁木齐市830000

出　　处：《临床合理用药杂志》2017年第7期18-19,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察普拉克索联合卡左双多巴缓释片(息宁)治疗中晚期帕金森病(PD)患者的临床疗效。方法将中晚期PD患者54例随机分为治疗组和对照组,每组27例,治疗组给予普拉克索联合息宁治疗,对照组给予息宁治疗。比较2组治疗前后帕金森综合评分量表(UPDRS)评分和不良反应。结果治疗前2组UPDRSⅡ评分和UPDRSⅢ评分比较差异均无统计学意义(P>0.05),治疗后2组UPDRSⅡ评分和UPDRSⅢ评分均下降(P<0.05),且治疗组低于对照组(P<0.05)。治疗组不良反应发生率为77.78%高于对照组的22.22%,差异有统计学意义(χ2=15.962,P<0.05)。结论普拉克索联合息宁治疗中晚期PD可显著改善帕金森病患者的运动障碍,提高其生存质量。但普拉克索不良反应不应忽视。Objective To observe the clinical effect of pramipexole combined with card left duobarb sustained release tablets in middle-late of parkinson＇s patients with movement disorders. Methods 54 cases patients with middle-late parkinson＇s were randomly divided into treatment group and control group,each of 27 cases. Treatment group was treated by pramipexole combined with card left duobarb sustained release tablets. Control group was treated by card left duobarb sustained release tablets. After treatment,compared the Parkinson＇s rating scale（ UPDRS） score before and after treatment and adverse effects of 2 groups.Results The score of UPDRSⅡ and UPDRSⅢ of 2 group before treatment was no statistic significantly（ P〉0. 05）. After treatment,the score of UPDRSⅡ and UPDRSⅢ of 2 groups were decreased（ P〈0. 05）,and the score of UPDRSⅡ and UPDRSⅢ in treatment group were lower than that of control group（ P〈0. 05）. The incidence of adverse reactions in treatment group（ 77. 78%） was higher than that of control group（ 22. 22%）,the difference was statistic significantly（ χ2= 15. 962,P〈0. 05）.Conclusion Pramipexole combined with card left duobarb sustained release tablets in middle-late of parkinson＇s patients with movement disorders can improve patients with movement disorders,improve their quality of life.

关 键 词：帕金森病 美多芭 普拉克索 卡左双多巴缓释片 

分 类 号：R742.5[医药卫生—神经病学与精神病学]