紫杉醇联合卡铂方案在三阴性乳腺癌新辅助化疗中的疗效  

Efficacy of neoadjuvant chemotherapy with paclitaxel plus carboplatin in patients with triple negative breast cancer

作　　者：陈燕玉[1] 周敏[1] 王旭禛[1] 唐晓燕[1] 陈翔[1] CHEN Yanyu ZHOU Min WANG Xuzhen(Department of Thyroid Breast Surgery,People＇s Hospital of Yixing, Yixing 214200, CHINA)

机构地区：[1]宜兴市人民医院甲乳外科,江苏省214200

出　　处：《江苏医药》2017年第6期401-403,共3页Jiangsu Medical Journal

摘　　要：目的探讨紫杉醇联合卡铂(PC)方案在三阴性乳腺癌新辅助化疗中的疗效。方法三阴性乳腺癌患者60例分为两组:PC组28例,紫杉醇175mg/m^2,第1天;卡铂400mg/m^2,第1天;PEC组32例,紫杉醇175mg/m^2,第1天;表柔比星75mg/m^2,第1天;环磷酰胺600mg/m^2,第1天。3周为1个疗程,4~6个疗程治疗后,评估疗效。结果 PC组完全缓解率高于PEC组(42.9%vs.12.5%)(P<0.05)。两组血液学毒性及消化系统毒性不良反应比较均无统计学差异(P>0.05)。结论 PC新辅助化疗方案可提高三阴性乳腺癌患者的化疗效果。Objective To observe the efficacy of neoadjuvant chemotherapy with paclitaxel plus carboplatin（PC）in the patients with triple negative breast cancer.Methods Sixty patients with triple negative breast cancer were divided into two groups of PC（treated with paclitaxel 175mg/m^2 and carboplatin 400 mg/m^2 on the first day,28cases）and PEC（treated with paclitaxel 175 mg/m^2,epirubicin 75mg/m^2 and cytoxan 600mg/m^2 on the first day,32cases）.After four to six courses of neoadjuvant chemotherapy,the efficacy was evaluated.Results The rate of complete remission of group PC was higher than that of group PEC（42.9%vs.12.5%）（P〈0.05）.There were no significant differences between two groups in the adverse effects,such as hematological toxicity and digestive system toxicity（P〉0.05）.Conclusion Neoadjuvant chemotherapy with PC regimen can improve the chemotherapeutic efficacy in the patients with triple negative breast cancer.

关 键 词：紫杉醇 卡铂 三阴性乳腺癌 

分 类 号：R737[医药卫生—肿瘤]