5-氨基酮戊酸光动力疗法治疗27例皮肤肿瘤疗效观察  

Efficacy of ALA-PDT in the treatment of cutaneous tumors

作　　者：陈年 雷霞 成琼辉 伍津津 CHEN Nian LEI Xia CHENG Qiong-hui et al(Department of Dermatology, the Third dffiliated Hospital of Third Military Medical University, Chongqing 400042, Chin)

机构地区：[1]第三军医大学第三附属医院皮肤科,重庆400042

出　　处：《实用皮肤病学杂志》2017年第1期1-3,共3页Journal of Practical Dermatology

摘　　要：目的探讨5-氨基酮戊酸光动力疗法(ALA-PDT)治疗皮肤肿瘤的临床疗效。方法对27例患者进行ALA-PDT治疗,其中包括角化棘皮瘤5例,光线性角化病12例,鲍恩病6例,增殖性红斑2例,疣状癌、鳞状细胞癌各1例。结果经过3~5次ALA-PDT治疗,角化棘皮瘤患者5例、光线性角化病患者11例、鲍恩病患者5例、增殖性红斑患者2例完全缓解,仅1例光线性角化病患者复发;疣状癌治疗无效;鳞状细胞癌完全缓解后又复发。结论 ALA-PDT因疗效好、损伤小、美容效果好、复发率低,适合皮损面积大、病变部位特殊的部分皮肤肿瘤,但对疣状癌、鳞状细胞癌效果欠佳。Objective To investigate the efficacy of 5-aminolaevulinic acid-photodynamic therapy（ALA-PDT） on cutaneous tumors. Methods ALA-PDT was adopted to treat 27 patients with cutaneous tumors, including 5 patients with keratoacanthoma, 12 patients with actinic keratosis, 6 patients with Bowen′s disease, 2 patients with erythroplasia of Queyrat, 1 patient with verrucous carcinoma, 1 patient with squamous cell carcinoma. Results The clearance was achieved in 5 patients with keratoacanthoma, 11 patients with actinic keratosis, 5 patients with Bowen′s disease, 2 patients with erythroplasia of Queyrat and 1 patient with squamous cell carcinoma. No response occurred in verrucous carcinoma. Except for 1 patient with actinic keratosis and the patient with squamous cell carcinoma, there were no other patients had recurrence. Conclusion Topical ALA-PDT is an effective, safe therapy with minor trauma, excellent cosmetic results and low recurrent rates for part of cutaneous tumors, which is a good alternative for patients with large lesions on special sites. But the effect may be not satisfi ed in verrucous carcinoma and squamous cell carcinoma.

关 键 词：肿瘤 皮肤 5-氨基酮戊酸 光动力疗法 

分 类 号：R739.5[医药卫生—肿瘤]