乌灵胶囊联合奥氮平治疗晚期肿瘤患者相关性焦虑、抑郁状态临床观察  

Clinical Observation of Wuling Capsules Combined with Olanzapine for Tumor-Associated Anxiety and Depression in Patients with Advanced Tumor

作　　者：杨雪飞[1,2] 叶知锋[1,2] 黄挺[1,2] 黄伶[1,2] 郭俊华[1,2] 蒋璐[1,2] 张建刚[1,2] 

机构地区：[1]杭州市中医院肿瘤科,浙江杭州310000 [2]浙江中医药大学附属广兴医院,浙江杭州310000

出　　处：《新中医》2017年第4期124-127,共4页New Chinese Medicine

基　　金：杭州市科技计划引导项目(2014KJJ05)

摘　　要：目的:观察乌灵胶囊联合奥氮平治疗晚期肿瘤患者相关性焦虑、抑郁状态的疗效及毒副反应。方法:将142例晚期恶性肿瘤伴肿瘤相关性抑郁、焦虑的患者随机分为对照组70例及观察组72例,2组除采用安慰、鼓励、帮助、同情及换位思考等心理支持治疗外,对照组予奥氮平,每天5 mg,睡前口服;观察组在对照组治疗方案的基础上加用乌灵胶囊,每次3粒,每天3次,口服。2组患者均连续治疗8周。采用Zung抑郁自评量表(SDS)和焦虑自评量表(SAS)评价焦虑、抑郁标准分变化,观察临床疗效,并进行世界卫生组织生存质量测定量表简表(WHOQOL-BREF)评分,记录药物使用期间的毒副反应。结果:治疗后,对照组与观察组总有效率分别为69.23%和94.35%,2组间比较,差异有统计学意义(P<0.05)。治疗后,2组SDS和SAD评分均降低,2组组内治疗前后比较,差异均有统计学意义(P<0.05);且观察组与对照组比较,差异有统计学意义(P<0.05)。治疗后,2组患者生理健康、心理状态、社会关系及周围环境等WHOQOL-BREF评分均较治疗前升高,差异均有统计学意义(P<0.05);且观察组WHOQOL-BREF评分与对照组比较,差异有统计学意义(P<0.05)。结论:乌灵胶囊联合奥氮平可有效改善晚期肿瘤患者相关性焦虑、抑郁状态,改善生活质量,临床应用方便,毒副作用小,患者可耐受。Objective：To observe the curative effect and toxic side effect of Wuling capsules combined with olanzapine on treating tumor-associated anxiety and depression in patients with advancedtumor.Methods：Divided 142 cases of patients with malignant tumor and tumor-associated anxiety and depression into the control group with 70 cases and the observation group with 72 cases randomly.Both groups received comfort,encouragement,help,sympathy,transposition thinking and other psychological supporting therapies.And the control group additionally received olanzapine orally near bedtime,with a dosage of 5 mg every day.On the basis of the treatment of the control group,the observation group additionally received Wuling capsules orally for three times a day,3 capsules for each time.Patients in both groups continuously received treatment for eight weeks.Assessed the changes of standard scores of anxiety and depression by applying Self-rating Depression Scale（SDS） and Self-Rating Anxiety Scale（SAS）.Observed the clinical effect and scored by the World Health Organization＇s Quality of Life Questionnaire-Brief Version（WHOQOL-BREF）.Recorded toxic side effect during medication.Results：After treatment,the total effective rate was 69.23%in the control group,and was 94.35%in the observation group,the difference being significant（P〈0.05）.After treatment,SDS scores and SAD scores in both groups were decreased when compared with those before treatment,differences being significant（P〈0.05）.Compared SDS scores and SAD scores in the observation group and those in the control group,differences being significant（P〈0.05）.After treatment,physiological health,psychological state,social relations,surrounding environment and other WHOQOL-BREF scores were increased,comparing with those before treatment,differences being significant（P〈0.05）.And the comparison of WHOQOL-BREF scores between the observation group and the control group showed significance in the difference（P〈0.05）.Conclusion：The therapy of

关 键 词：恶性肿瘤 抑郁 焦虑 乌灵胶囊 奥氮平 抑郁自评量表(SDS) 焦虑自评量表(SAS) 世界卫生组织生存质量测定量表简表(WHOQOL-BREF) 

分 类 号：R730.5[医药卫生—肿瘤]