养血清脑颗粒对老年脑梗死后抑郁患者血清胱抑素C及认知功能的影响  

Effects of Yangxue Qingnao Granule on the Levels of Serum Cystatin C and Cognition Function in Senile Patients with Depression after Cerebral Infarction

作　　者：王晓萍[1] 彭军[1] 姜丹[1] 黄丹[1] 刘孙琴[2] 

机构地区：[1]武汉科技大学附属天佑医院神经内科,湖北武汉430000 [2]武汉科技大学附属天佑医院检验科,湖北武汉430000

出　　处：《现代生物医学进展》2017年第8期1477-1479,1573,共4页Progress in Modern Biomedicine

基　　金：湖北省自然科学基金项目(2011AB730)

摘　　要：目的:探究养血清脑颗粒对老年脑梗死后抑郁患者血清胱抑素C水平的影响及认知功能水平的影响。方法:选取2015年6月到2016年6月我院神经内科收治的老年脑梗死后抑郁患者74例,根据随机数字对照表分为对照组与试验组,各37例。对照组采用口服盐酸帕罗西汀治疗,试验组联合给予养血清脑颗粒治疗,4周为一个疗程,共治疗一个疗程。比较两组患者临床疗效、血清胱抑素C水平及认知功能水平。结果:治疗结束后,与对照组相比,试验组临床总有效率较高(P<0.05),治疗后两组血清胱抑素C水平较治疗前降低(P<0.05),MMSE评分较治疗前升高(P<0.05);与对照组相比,血清胱抑素C水平较低(P<0.05),MMSE评分较高(P<0.05)。结论:养血清脑颗粒治疗老年脑梗死后抑郁患者临床疗效显著,认知功能明显改善,推测其与血清胱抑素C水平降低有关。Objective： To investigate the effects of yangxue qingnao granule on the levels of serum cystatin C and cognition function in senile patients with depression after cerebral infarction. Methods： 74 patients with senile patients with depression after cerebral infarction who were treated in our hospital neurology department from June 2015 to June 2016 were selected, and randomly divided into control group and experiment group, with 37 cases in each group. The patients in the control group were treated with conventional drugs treatment, oral paroxetine hydrochloride, and the patients in the experiment group were treated with conventional drugs treatment combined with yangxue qingnao granule. 4 weeks were for a course of treatment, a total of a course of treatment. After treatment, the clinical efficacy, serum C cystatin and cognitive fimction levels were compared between in the two groups. Results： After treatment, compared with the control group, the clinical total effective rate of the experiment group was higher （P 〈 0.05）, and the serum cystatin C level of the two groups were lower than before treatment after treatment （P 〈 0.05）, the MMSE scored was higher than before treatment （P 〈 0.05）; compared with control group, the serum cystatin C level of the experiment group was lower （P 〈 0.05）, MMSE scored was higher （P 〈 0.05）. Conclusions： Yangxue qingnao granule in the treatment of？patients with senile depression after cerebral infarction has remarkable clinical effect, and can significantly improve cognitive function, which may be relate to reduction of serum cystatin C level.

关 键 词：养血清脑颗粒 脑梗死 抑郁 血清胱抑素C 认知功能 

分 类 号：R743[医药卫生—神经病学与精神病学]