炎症评分与晚期胰腺癌患者预后相关性研究  

The Correlation between Inflammatory Score and Prognosis of Patients with Advanced Pancreatic Cancer

作　　者：徐熙[1,2] 马洪生[3] 刘蓉安[4] 向露[5] 张维[5] 陈韵[6] 

机构地区：[1]四川大学华西医院消化科,四川成都610041 [2]四川省人民医院消化科,四川成都610041 [3]四川大学华西医院消化内科,四川成都610041 [4]四川省人民医院外科ICU,四川成都610041 [5]四川省人民医院老年内科,四川成都610041 [6]四川省人民医院老年消化科,四川成都610041

出　　处：《现代生物医学进展》2017年第9期1663-1666,1614,共5页Progress in Modern Biomedicine

基　　金：四川省卫生厅科研课题(130236)

摘　　要：目的:评估炎症评分对接受放化疗(CRT)的局部晚期胰腺癌患者的无进展生存期(PFS)和总生存期(OS)的预测价值。方法:选取235例晚期胰腺癌患者,接受治疗前,所有患者均进行临床评估、实验室检查和影像学检查。比较两组患者的PFS和OS;评估与患者预后差、肿瘤减少率、6个月内肿瘤转移相关的预测因子。结果:患者平均PFS和OS分别为10.2个月和18.8个月。格拉斯哥预后评分(GPS)2、血浆纤维蛋白原(FIB)≥400 mg/dL为PFS和OS较差的的独立预测因素;小野寺预后营养指数(OPNI)是CRT后肿瘤减少率提高的预测因子(P<0.05);GPS 2、FIB≥400 mg/dL的患者的早期转移发生率显著提高(P<0.05)。结论:格拉斯哥预后评分、纤维蛋白原、小野寺预后营养指数是评估接受放化疗治疗的局部晚期胰腺癌患者有效的治疗和预后预测因子。Objective： To evaluate the predictive value of the inflammatory score for the progression bee survival （PFS） and overall survival （OS） of patients with locally advanced pancreatic cancer undergoing radiotherapy and chemotherapy （CRT）. Methods： 235 patients with advanced pancreatic cancer were selected. All patients underwent clinical evaluation, laboratory examination and imaging examination before treatment. The PFS and OS were compared between the two groups, and the predictive factors were evaluated on the prognosis of patients with poor prognosis, tumor reduction rate, and tumor metastasis within 6 months. Results： The average PFS and OS of the patients were 10.2 months and 18.8 months, respectively. Glasgow prognosis score （GPS） 2 and plasma flbrinogen （FIB）〉 400mg/dL were independent predictors of poor PFS and OS. Onokazu Temple prognostic index （OPNI） was a predictor of increased tumor reduction rate after CRT （P〈0.05）. Patients with GPS 2 and FIB〉 400mg/dL had early metastasis rate increased significantly （P〈0. 05）. Conclusions： Glasgow prognosis score, fibrinogen, and OPNI are effective predictors for prognosis of patients with locally advanced pancreatic cancer treated with radiotherapy and chemotherapy.

关 键 词：晚期胰腺癌 炎症评分 预后 

分 类 号：R735.9[医药卫生—肿瘤]