宫颈癌组织中的PTEN,VEGF和CD105的表达及临床意义  

Expression of the PTEN,VEGF and CD105 in Cervical Cancer Tissues and its Clinical Significance

作　　者：陈舒[1] 罗新[1] 帅翰林[1] 周宏[1] 梁耀中[2] 

机构地区：[1]暨南大学附属第一医院妇产科,广东广州510630 [2]暨南大学附属第一医院骨科,广东广州510630

出　　处：《现代生物医学进展》2017年第9期1696-1699,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨宫颈癌组织中的人第10号染色体缺失的磷酸酶及张力蛋白同源基因(PTEN)、血管内皮生长因子(VEGF)和内皮因子(CD105)的表达及临床意义。方法:收集2010年1月至2016年2月我院收治的宫颈癌患者组织标本320例和同期正常宫颈组织标本100例,采用SP免疫组化法检测宫颈癌和正常宫颈组织中的PTEN、VEGF和CD105,分析各指标在宫颈癌、正常宫颈组织及不同类型宫颈癌组织中的表达,并采用Sperman分析三者相关关系。结果:宫颈癌组织VEGF阳性率、CD105-MVD高于正常宫颈组织,而PTEN阳性率低于正常宫颈组织,差异均有统计学意义(P<0.05);宫颈癌组织FIGO分期Ⅰ~Ⅱ期的VEGF阳性率、CD105-MVD低于Ⅲ~Ⅳ期,而PTEN阳性率高于Ⅲ~Ⅳ期;宫颈癌组织伴有淋巴结转移的VEGF阳性率、CD105-MVD高于无转移,而PTEN阳性率低于无转移,差异均有统计学意义(P<0.05);Sperman相关性显示VEGF与PTEN,CD105-MVD与PTEN呈现明显的负相关关系(rs=-0.564,-0.893,P<0.05),VEGF与CD105-MVD呈现正相关关系(rs=0.825,P<0.05)。结论:PTEN在宫颈癌组织表达降低,CD105和VEGF升高,三个指标在宫颈癌的发生、发展、转移及预后中具有重要作用。Objective： To explore the expression of the phosphatase and tensin homolog deleted on chromosome ten （PTEN）, vascular endothelial growth factor （VEGF） and endothelial factors （CD105） in cervical cancer tissues and its clinical significance. Methods： 320 cases of cervical cancer tissue specimens and 100 cases of normal cervical tissue specimens in our hospital from January 2010 to February 2016 were selected, the PTEN, VEGF and CD105 in cervical cancer and normal cervical tissues were detected by SP immunohistochemieal method. The expression of each index in the cervical cancer tissues, normal cervical tissues and different types of cervical cancer tissues were analysed. And Sperman was used to analyz the relationship between the three. Results： The positive rate of VEGF and CD105-MVD of cervical cancer tissues were higher than normal cervical tissues, and the positive rate of PTEN was lower than that of normal cervical tissues, the difference was statistically significant （P〈0.05）. The positive rate of VEGF and CD105-MVD of FIGO stage Ⅰ - Ⅱ of cervical cancer tissues were lower than FIGO stage Ⅲ-Ⅳ, and the positive rate of PTEN was higher than FIGO stage Ⅲ- Ⅳ. The positive rate of VEGF and CD105-MVD with lymph node transfer of cervical cancer tissues were higher than no transfer, and the positive rate of PTEN was lower than no transfer,the difference was statistically significant （P〈0.05）; The Sperman correlation display, VEGF and PTEN, CD105-MVD and PTEN showed a significant negative correlation （rs=-0.564, -0.893, P〈0.05）, and the VEGF showed a positive correlation with CD105-MVD （rs=0.825, P〈0.05）. Conclusion： The decrease of expression of PTEN and the increase of CD105 and VEGF in cervical cancer tissue show indicating that these three indicators play an important role in the occurrence, development, metastasis and prognosis of cervical cancer.

关 键 词：宫颈癌 PTEN VEGF CD105 临床意义 

分 类 号：R737.33[医药卫生—肿瘤]