海洋生物ACE抑制肽研究进展  

Advance on Angiotensin-I-converting Enzyme Inhibitory Peptides From Marine Resources

作　　者：操德群[1] 何艳丽[1,2] 余虹[1] 徐晓婷[1] 徐年军[1] 

机构地区：[1]宁波大学海洋学院/应用海洋生物技术教育部重点实验室,浙江宁波315211 [2]浙江医药高等专科学校,浙江宁波315100

出　　处：《核农学报》2017年第5期927-937,共11页Journal of Nuclear Agricultural Sciences

基　　金：浙江省教育厅科研项目(Y201432453);宁波市科技局科技富民计划项目(2016C10034)

摘　　要：血管紧张素转化酶(ACE)抑制肽是一类通过抑制ACE活性实现降压作用的多肽类物质。天然来源的ACE抑制肽具有安全性高、毒副作用小、可长期服用等优点,目前已经从陆源性植物蛋白、动物蛋白中发现了多种ACE抑制肽。海洋生物是一类重要的新型生物资源,含有大量的蛋白质类物质,通过降解可得到ACE抑制肽。本文运用生物信息学检索方法,对国内外主要海洋生物ACE抑制肽的研究进行了综述,主要从材料来源、降解酶、氨基酸序列以及IC50值4个方面重点介绍海洋鱼、虾、贝、藻等来源的ACE抑制肽,比较了其可能的区别和特征,并对海洋生物ACE抑制肽应用前景进行了展望,旨在为开发和利用海洋生物蛋白,促进海洋生物活性物质的研发提供指导。ACE inhibitory peptides are a class of peptides inhibiting ACE activity to achieve antihypertensive effects. Compared with synthetic counterparts, ACE inhibitory peptides from nature sources are considered to be safe, few side effects and can be long-term taken. A variety of ACE inhibitory peptides derived from terrestrial plant and animal protein were reported. Marine creatures are a new kind of important bio-resources with multiple protein structures, which can produce new ACE inhibitory peptides. In this paper, the research advances on the ACE inhibitory peptides derived from marine resources were reviewed by bioinformatics retrieval method. The ACE inhibitory peptides from marine fish, shrimp, shellfish, algae, and other marine creatures were reviewed, and mainly focused on the material resources, enzyme, amino acid sequence, and IC50 values. In addition, the application prospects of ACE inhibitory peptides from marine resources were discussed as well. This review is benefited for the development and utilization of marine proteins, and important for the research and development of marine bioactive substances.

关 键 词：ACE抑制肽 海洋生物蛋白 血管紧张素转化酶 降血压 

分 类 号：Q51[生物学—生物化学]