缺血性脑血管病患者血清同型半胱氨酸、叶酸和维生素B12水平与头颈部血管狭窄的相关性研究  

Correlation Study between Serum Homocysteine,Folate,Vitamin B12 Levels and Head and Neck Vascular Stenosis in Patients with Ischemic Cerebrovascular Disease

作　　者：左林[1] 赵佳[2] 姜小建[2] 李燕燕[1] 崔光彬[1] 

机构地区：[1]第四军医大学唐都医院放射科,西安710038 [2]西安市中心医院检验科,西安710003

出　　处：《现代检验医学杂志》2017年第2期23-25,29,共4页Journal of Modern Laboratory Medicine

摘　　要：目的探讨缺血性脑血管病患者血清同型半胱氨酸(Homocysteine,HCY)、叶酸、维生素B12水平与头颈部血管狭窄的相关性。方法将2016年4月~10月入住第四军医大学唐都医院的缺血性脑血管病患者225例纳入研究,检测患者血清HCY,叶酸及维生素B12水平。应用CT血管成像(CT angiography,CTA)技术,对患者行头颈部CTA扫描,根据血管有无狭窄,分为血管无狭窄组和血管有狭窄组,按血管狭窄程度,分为血管无狭窄组、轻中度狭窄组和重度狭窄组。结果头颈部血管有狭窄组HCY水平显著高于血管无狭窄组,叶酸及维生素B12水平显著低于血管无狭窄组,差异具有统计学意义(t=9.656,7.140和8.350,均p<0.01)。轻中度狭窄组及重度狭窄组HCY水平显著高于无狭窄组,重度狭窄组HCY水平显著高于轻中度狭窄组,差异具有统计学意义(t=6.108,9.401和5.273,均P<0.01),轻中度狭窄组及重度狭窄组叶酸水平显著低于无狭窄组,差异具有统计学意义(t=5.574,5.988,均P<0.01),轻中度狭窄组及重度狭窄组维生素B12水平显著低于无狭窄组,差异具有统计学意义(t=4.548和7.816,均P<0.01)。头颈部血管狭窄程度与血清HCY水平呈正相关(r=0.331,P<0.01),头颈部血管狭窄程度与维生素B12水平呈负相关(r=-0.279,P<0.05)。结论HCY,叶酸和维生素B12水平与头颈部血管狭窄程度具有密切的相关性。对缺血性脑血管病患者行HCY,叶酸和维生素B12检测及头颈部CTA检查具有重要的临床价值。Objective To investigate the correlation between HCY （Homocysteine）, folate, vitamin B12 and head and neck vascular stenosis in patients with ischemic cerebrovascular disease. Methods 225 patients with ischemic cerebrovascular dis- ease in Tangdu Hospital of the Fourth Military Medical University were enrolled in the study from April 2016 to October 2016. The serum levels of HCY,folate and vitamin B12 were detected. CT angiography （CTA） was uesd for patients with head and neck vascular scanning. According to whether the presence of vascular stenosis, patients were classified as no vessel stenosis group and vascular stenosis group. According to the degree of stenosis,patients were classified as no vascular steno- sis group,mild moderate stenosis group and severe stenosis group. Results The HCY levels in the vascular stenosis group were significantly higher than no vessel stenosis group, while the levels of folate and vitamin B12 were significantly lower than no vessel stenosis group, the differences were statistically significant （t= 9. 656,7. 140 and 8. 350, all P〈0.01）. The HCY levels in mild moderate stenosis group and severe stenosis group were significantly higher than no vessel stenosis group, and the HCY levels in severe stenosis group were significantly higher than mild moderate stenosis group,the differ- ences were statistically significant （t= 6. 108,9. 401 and 5： 273, all P % 0.01）. The folate levels in mild moderate stenosis group and severe stenosis group were significantly lower than no stenosis group,the differences were statistically significant （t= 5. 574 and 5. 988 ,all P〈0.01）. The vitamin B12 levels in mild moderate stenosis group and severe stenosis group were significantly lower than no stenosis group,the differences were statistically significant （t= 4. 548 and 7. 816, all P〈0.01） The degree of head and neck vascular stenosis and serum levels of HCY were positively correlated （r= 0. 331,P〈0.01）The degree of head and neck vascular.stenosis and levels of v

关 键 词：同型半胱氨酸 叶酸 维生素B12 头颈部血管 CT血管成像 

分 类 号：R743[医药卫生—神经病学与精神病学] R446.112[医药卫生—临床医学]