血清幽门螺杆菌抗体对消化性溃疡患者的临床意义  

Clinical significance of serum Helicobacter pylori antibody in peptic ulcer

作　　者：高琳[1] 陈文举[1] 朱敏琦[1] 

机构地区：[1]台州市中心医院(台州学院附属医院)检验中心,浙江台州318000

出　　处：《中国卫生检验杂志》2017年第6期851-852,856,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨血清幽门螺杆菌(Hp)抗体对消化性溃疡患者的临床意义。方法选取幽门螺杆菌感染的消化性溃疡患者298例,免疫印迹法检测血清Hp抗体,分析抗体阳性表达情况与不同消化性溃疡患者的关系。结果在消化性溃疡的现症患者中,Hp抗体以Ⅰ型为主,阳性率为77.85%,显著高于Ⅱ型抗体阳性率,差异有统计学意义(P<0.01)。十二指肠溃疡HpⅠ型抗体阳性率高于胃溃疡,差异有统计学意义(P<0.05)。HpⅠ型感染者中以CagA+VacA抗体为主,阳性率为79.74%;各组中CagA+VacA抗体阳性率显著高于单一的CagA或VacA抗体阳性率,差异均有统计学意义(P<0.01)。结论 Hp血清学检测对消化性溃疡患者的诊断和治疗均有重要临床指导意义,Ⅰ型Hp菌株抗体阳性的患者更应得到临床重视。Objective To explore the clinical significance of serum Helicobacter pylori（ Hp） antibody in peptic ulcer. Mothods 298 patients diagnosed as peptic ulcer with helicobacter pylori infection were selected to analyze the positive rate of positive antigean and connection with peptic ulcer. Results In patients with peptic ulcer,Hp antibody was dominated by type Ⅰ,and its positive rate was 77. 85%,which was significantly higher than that of Hp Ⅱ,with the differences statistically significant（ P〈0. 01）. The positive rate of Hp Ⅰ antibody in duodenal ulcer was significantly higher than that in gastric ulcer,with the differences statistically significant（ P〈0. 05）. The positive rate of Hp Ⅰ antibody,mainly CagA ＋ VacA antibody,was79. 74%,which was significantly higher than that of either CagA or VacA antibody,with the differences statistically significant（ P〈0. 01）. Conclusion Serum Hp antibody has important clinical significance for diagnose and treatment of peptic ulcer,and patients with type Hp antibody I positive should be given more attention in clinical practice.

关 键 词：幽门螺杆菌抗体 消化性溃疡 分型 

分 类 号：R573.1[医药卫生—消化系统]