海洛因依赖者前额叶皮层与海马温度改变的磁共振波谱测量  

Measurement of prefrontal cortex and hippocampus temperature change with magnetic resonance spectroscopy for heroin addicts

作　　者：梁文彬[1,2] 孙新珺 张琨[3] 申云霞[2] 娄明武[2] 

机构地区：[1]广州中医药大学,广东 广州 510006 [2]深圳市龙岗中心医院医学影像科,广东深圳518116 [3]深圳市公安局戒毒专科医院,广东深圳518019

出　　处：《实用放射学杂志》2017年第4期493-496,共4页Journal of Practical Radiology

基　　金：国家自然科学基金项目（81471661）.

摘　　要：目的 探讨磁共振波谱（MRS）技术测量海洛因依赖者前额叶皮层与海马温度变化的可行性及意义.方法 对18例处于戒断治疗期的海洛因依赖者和18例健康志愿者（对照组）分别于静息态和视觉刺激（呈现海洛因相关图片）诱导渴求状态下进行单体素MRS扫描,测量前额叶皮质和双侧海马N-乙酰基天门冬氨酸（NAA）化学位移值,通过修正后的温度-NAA化学位移方程,计算其脑温度.结果 海洛因依赖组静息态前额叶皮层脑温度较对照组上升,差异有统计学意义（P〈0.05）,并且其脑温度值与吸食总量呈正相关（P〈0.05）;但比较静息态与视觉刺激态前额叶皮层及海马温度无显著统计学差异（P〉0.05）.结论 MRS可无创性测量脑温度,脑温度的异常改变有助于探讨药物成瘾与渴求机制.Objective To investigate temperature changes in prefrontal cortex and hippocampus of heroin addicts with magnetic resonance spectroscopy （MRS）.Methods 18 heroin addicts in the withdrawal state and 18 healthy volunteers （control group） were performed with MRS scan.First, resting-state MRS scan was performed on all subjects, and then did MRS scan again under visual stimulation while subjects were asked to carefully watch the heroin-related cue images.Measurements of NAA of the identified regions （the prefrontal cortex, bilateral hippocampus） were obtained from all subjects.Brain temperatures were calculated by the modified brain temperature-chemical shift equation.Results In resting state, the temperature of prefrontal cortex in heroin addicts group was higher than the control group, the difference was statistically significant （P〈0.05）,and the brain temperature was positively correlated with total dose of heroin （P〈0.05）.The prefrontal cortex/hippocampus temperature of heroin addicts group did not showed statistical significance between resting state and visual stimulation state （P〉0.05）.Conclusion MRS can be used to measure brain temperature noninvasively.Temperature change of brain may be helpful for exploring the mechanism of drug addiction and craving.

关 键 词：脑温度 药物依赖 磁共振波谱 

分 类 号：R742[医药卫生—神经病学与精神病学] R322.81[医药卫生—临床医学]