高血铅与儿童冲动-多动行为的关系研究  

Impacts of elevated blood lead level on children's hyperactivity/impulsivity

作　　者：林燕芬[1] 徐健[1] LIN Yanfen XU Jian(Department of Developmental and Behavioural Pediatrics, MOE-Shanghai Key Laboratory of Children＇s Environmental Health, Shanghai Institute for Pediatric Research, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, Chin)

机构地区：[1]上海交通大学医学院附属新华医院发育行为儿童保健科教育部和上海市环境与儿童健康重点实验室上海市儿科医学研究所,中国上海200092

出　　处：《教育生物学杂志》2017年第1期21-24,共4页Journal of Bio-education

基　　金：国家自然科学基金(81373016;81673189)

摘　　要：目的探讨高血铅对儿童行为的影响。方法选择血铅水平≥100μg/L的88例儿童作为高血铅组,血铅水平<100μg/L的66例儿童作为对照组。采用铅中毒门诊问卷收集儿童一般信息与铅暴露来源,采用《Conners儿童行为量表》对两组儿童的品行问题、学习问题、心身障碍、冲动-多动、焦虑和多动指数6个行为因子进行评估,用多因素二元Logistic回归对血铅与儿童行为问题的关系进行分析。结果对照组儿童母亲教育水平与家庭年总收入比高血铅组儿童高。在矫正相关混杂因素后,相对于对照组儿童而言,高血铅组儿童出现冲动-多动以及多动指数异常的风险分别为2.9(95%CI:1.1,8.0;P=0.035)和2.9(95%CI:1.1,7.9;P=0.037)。结论高血铅组儿童发生冲动-多动行为的风险较正常儿童高,对于血铅偏高的儿童,应采取积极有效的预防与干预措施,以促进儿童健康成长。Objective To investigate the effect of elevated blood lead levels on children＇s behaviors. Methods A total of 88 children with blood lead level ≥ 100μg/L and 66 children with blood lead level 〈100 μg/L were recruited as the lead exposure group and the control group, respectively. Administrated questionaires were used to collect the sociodemographic characteristics and lead exposure sources of subjects. Child Behavior Rating Scale was used to evaluate the conduct problems, learning problems, psychosomatic disorder, impulsivity-hyperactivity, anxiety, and hyperactivity index in both groups. Multivariable binary logistic regression models were used to associate blood lead and children＇s behaviors. Results Maternal education level and family yearly income were higher in the control group than in the exposure group. Compared with the control group, the exposure group had higher risks of behavioral problems in the domains of impulsivity- hyperactivity （ OR = 2. 9 ; 95% CI： 1.1, 8.0 ; P = 0. 035 ） and hyperactivity index （ OR = 2. 9 ; 95% CI： 1.1, 7.9 ; P = 0. 037 ）. Conclusion High levels of lead have an adverse effect on child hyperactivity/impulsivity behaviors. Effevtive measurements are required to ensure the healthy growth of children.

关 键 词：高血铅 冲动-多动 儿童 

分 类 号：R749.94[医药卫生—神经病学与精神病学]