间歇有氧运动降低血压的机制  

Mechanism of intermittent aerobic exercise lowering blood pressure

作　　者：李宏伟[1] 王梁[1] 赖敏[1] Hong-wei Li Liang Wang Min Lai(School of Sport, Gannan Normal University, Ganzhou, Jianxi 341000, China)

机构地区：[1]赣南师范大学体育学院,江西赣州341000

出　　处：《中国现代医学杂志》2017年第7期15-19,共5页China Journal of Modern Medicine

摘　　要：目的研究间歇有氧运动(IAE)对自发性高血压大鼠(SHR)血压的影响,探讨运动防治高血压的方法和机制。方法 SHR30只,分为间歇有氧运动组(IAE组)和对照组(C组)。IAE组进行8周的间歇跑台有氧运动。运动前后测量血压、血脂;应用免疫组织化学法显示心肌及冠状血管肾上腺髓质素(ADM)的表达,免疫印记法检测心肌ADM的特异性受体RAMP2和CRLR的定量。结果 IAE组血压和血脂低于C组(P<0.05),心肌及冠状血管ADM表达强于C组;ADM含量及心肌RAMP2和CRLR定量均上升(P<0.05)。结论间歇有氧运动使SHR的血压、血脂降低,心肌及冠状血管ADM表达增强,含量升高,其特异性受体CRLR和RAMP2上调,间歇有氧运动引起的血压下降可能与ADM的变化及其特异性受体的调节改变有关,这可能是间歇有氧运动防治高血压的机制之一。Objective To probe the effect of intermittent aerobic exercise on blood pressure of spontaneous hypertensive rat （SHR）, and investigate the methods and mechanism of exercise in the prevention and treatment of hypertension. Methods Thirty SHR were separated into intermittent aerobic exercise group （group IAE ） and control group （group C）. The group IAE performed 8 weeks of intermittent treadmill exercise, and their blood pressure and blood lipid were measured before and after exercise. Immunohistochemistry was used to detect the expression of adrenomedullin （ADM） in myocardium and coronal2~ vessels. Immunoblotting was applied for quantification of specific receptors RAMP2 and CRLR of ADM in cardiac muscle. Results Blood pressure and blood lipid in the group IAE were significantly lower than those in the group C （P 〈 0.05）. The expression of ADM in myocardium and coronary vessels of the group IAE was obviously higher than that in the group C. The content of ADM, RAMP2 and CRLR in the cardiac muscle was obviously increased in the group IAE （P 〈 0.05）. Conclusions Intermittent aerobic exercise reduces blood pressure and blood lipid of SHR, increases the expression of ADM in myocardium and coronary vessels, and up-regulate their specific receptors CRLR and RAMP2. The decrease in blood pressure caused by intermittent aerobic exercise may be related to the change of ADM and the regulation of its specific receptors, which could be one of the mechanisms of intermittent aerobic exercise in the prevention and treatment of hypertension.

关 键 词：间歇有氧运动 自发性高血压大鼠 肾上腺髓质素 肾上腺髓质素特异性受体 

分 类 号：R-332[医药卫生]