高尔基体蛋白73在甲胎蛋白阴性原发性肝癌患者中的诊断意义  

Golgi protein 73 in AFP-negative diagnosis of primary liver cancer patients

作　　者：马娟[1] 张爱芸[1] 王煜[1] 张旭[2] 马燕[2] 刘鑫[2] 

机构地区：[1]宁夏医科大学总医院感染疾病科,宁夏银川750004 [2]宁夏医科大学,宁夏银川750004

出　　处：《宁夏医学杂志》2017年第4期298-300,共3页Ningxia Medical Journal

摘　　要：目的探讨高尔基体蛋白73(GP73)在甲胎蛋白(AFP)阴性的原发性肝细胞肝癌(HCC)患者中的诊断意义。方法依据研究对象的纳排标准,将入组的112例HCC患者分组,其中乙肝相关性原发性肝癌患者(HBsAg阳性组)79例,非乙肝相关性原发性肝癌患者(HBsAg阴性组)33例;而APP阴性患者(AFP<20μg/L)65例,AFP阳性患者(AFP>20μg/L)47例。检测112例入组患者的空腹血清GP73、AFP水平,对各组中二者水平是否阳性及HBsAg是否阳性进行统计学分析。结果比较112例肝癌患者HBsAg阳性和阴性的GP73表达,结果显示,HBsAg阳性组与HBsAg阴性组血清GP73、AFP水平均明显升高,但2组差异无统计学意义(P>0.05)。血清GP73单项检测阳性患者74例,阳性率66.07%;血清AFP单项检测阳性患者47例,阳性率41.96%;血清GP73及AFP联合检测阳性患者68例,阳性率60.71%,与血清AFP单项检测阳性率、阴性率比较,血清GP73、血清GP73联合AFP差异均有统计学意义(P<0.05)。65例血清AFP阴性患者,GP73检测阳性患者39例,阳性率达60%,与血清AFP单项检测相比较,差异有统计学意义(P<0.05)。结论血清GP73在肝癌患者中表达与HBsAg是否阳性无相关性,对AFP阴性的肝癌患者,其对肝癌补充诊断方面具有一定临床价值。Objective To discussed the diagnostic significance of Golgi protein 73 in AFP - negative patients with primary liver cancer. Methods According to the criterion of study, 112 cases of Hepatocellular Carcinoma（HCC） patients were enrolled the group, in- cluding 79 cases of HBV - related HCC patients（ HBsAg positive group） and 33 cases of non - HBV - related HCC patients（ HBsAg negative group）. AFP - negative patients （ AFP 〈 20 μg/L） were 65 cases and AFP - positive patients （ AFP 〉 20 μg/L） were 47 cases. 112 patients were detected μthe fasting serum GP73 and AFP levels, which were analyzed. Results The levels of GP73 and AFP were significantly increased in HBsAg positive and HBsAg negative groups, there was no significant difference （P 〉 0.05）. Of the 112 patients with liver cancer, there were 74 patients tested the GP73 single, the positive rate was 66.07% and there were 47 patients tested the AFP single ,the positive rate was 41.96%. There were 68 cases whose GP73 and AFP were all positive,the positive rate were 60.71%. Compared with the AFP positive rate and the negative rate, the GP73 and the joint of GP73 and AFP were statistically significant （ P 〈 0. 05 ） ,65 cases of serum AFP negative patients, GP73 test positive in 39 patients, the positive rate was 60%, with serum AFP single detection contrast, the difference was statistically significant（P 〈 0. 05 ）. Conclusion GP73 expression in the serum is not correlation with the HBsAg. It has some clinical value to the AFP - negative patients with liver cancer.

关 键 词：原发性肝癌 高尔基体蛋白73 甲胎蛋白 

分 类 号：R735.7[医药卫生—肿瘤]