人参四逆汤加味治疗不同类型实体瘤患儿化疗不良反应的临床效果分析  

Clinical Effect Analysis of Modified Renshen Sini Decoction Treating Different Types of Solid Tumor Patients with Adverse Reactions due to Chemotherapy

作　　者：冯克久 张作美[1] 程婉[1] 吕英[1] 

机构地区：[1]南方医科大学南方医院,广东广州510515

出　　处：《辽宁中医杂志》2017年第4期753-755,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：广东省中医药局中医药强省建设专项资金;广东省名中医师承项目(2100601)

摘　　要：目的:探讨人参四逆汤加味治疗不同类型实体瘤患儿化疗不良反应的临床效果分析。方法:将2015年1月—2016年6月在本院儿科治疗的80例不同类型实体瘤患儿随机分为两组,均采用化疗治疗的方法,出现化疗不良反应,对照组采用西医常规治疗的方法,在此基础上观察组采用人参四逆汤加味治疗,6个月后比较两组患儿疲乏、恶心呕吐、纳差、白细胞低下等不良反应的改善情况、外周血象各指标、化疗依从性以及生活质量。结果:观察组治疗后疲乏、恶心呕吐、纳差、体重减轻、脱发等不良反应明显较对照组减轻,差异有统计学意义(P<0.05);观察组治疗后白细胞计数、血小板计数、血红蛋白浓度明显高于对照组,差异有统计学意义(P<0.05);观察组化疗依从性及化疗完成率均高于对照组,差异有统计学意义(P<0.05);观察组治疗后生活质量改善情况明显优于对照组,差异有统计学意义(P<0.05)。结论:人参四逆汤加味治疗不同类型实体瘤患儿化疗不良反应的临床效果显著,有效减轻化疗对机体的损伤,增强耐受性,提高生活质量,具有积极的临床意义。Objective ： To investigate the clinical effect of Modified Renshen Sini Decoction in the treatment of different types of solid tumor patients with adverse drug reactions due to chemotherapy. Methods：During January 2015--June 2016 in our hospital, 80 cases of different types of solid tumor patients were randomly assigned for two groups. The two groups were treated with routine chemotherapy while the control group was treated with routine treatment of Western medicine, based on this observation group used Modified Renshen Sini Decoction. After 6 months, we compared the two groups＇ fatigue, nausea, vomiting, anorexia,low leucocyte, chemotherapy compliance and quality of life. Results ： After treatment in the observation group, fatigue, nausea, vomiting, anorexia, weight loss, hair loss and other adverse reactions were significantly milder than those in the control group. The difference was sta-tistically significant （ P 〈 0.05 ）. After treatment in observation group, white blood cell count, platelet count and hemoglobin con- centration weresignificantly higher than those of the control group. The difference was statistically significant （ P 〈 0.05 ）. The ob- servation group＇s compliance rate for chemotherapy and chemotherapy completion rates were higher than those in the control group. The difference was statistically significant （ P 〈 0.05 ）. After treatment in observation group, quality of life improvement was better than that of the control group. The difference was statistically significant （ P 〈 O. 05 ）. Conclusion ：The clinical effect of Mod- ified Renshen Sini Decoction in the treatment of different types of solid tumors in children with adverse reaction due to chemother- apy is significant. It can effectively reduce the damage of chemotherapy on the body, enhance tolerance and improve the quality of life, with positive clinical significance.

关 键 词：不同类型实体瘤 儿童 化疗不良反应 人参四逆汤加味 临床效果 

分 类 号：R73[医药卫生—肿瘤]