复方苦参注射液联合奈达铂治疗恶性胸腔积液的临床疗效观察  

Efficacy of Compound Kushen Injection Combined with Nedaplatin for Malignant Pleurai Effusion

作　　者：李瑞林[1] 于江涛[1] 张沙沙[1] 王爱蓉[1] 

机构地区：[1]威海市立医院肿瘤科,山东威海264200

出　　处：《辽宁中医杂志》2017年第4期789-790,共2页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的:观察复方苦参注射液联合奈达铂治疗恶性胸腔积液的临床疗效。方法:将全部恶性胸腔积液患者72例,采用随机抽样方法分为治疗组与对照各36例。治疗组在胸水引流后采用复方苦参注射液联合奈达铂和地塞米松胸腔内注射治疗,药物剂量为复方苦参注射液30 m L、0.9%氯化钠注射液50 m L、奈达铂60 mg、地塞米松10 mg。对照组在胸水引流后单纯采用奈达铂合地塞米松胸腔内注射治疗,药物剂量同治疗组。治疗5~7 d后重复治疗1次,最多重复4次。治疗结束后观察两组疗效、生活质量、不良反应情况,并作比较。结果:治疗组总缓解率和生存质量KPS评分改善稳定率明显高于对照组(P<0.05);治疗组消化道症状和白细胞计数下降发生率明显低于对照组(P<0.05)。结论:复方苦参注射液联合奈达铂疗法可有效提高恶性胸腔积液疗效,改善患者生存质量。Objective：To evaluate the efficacy and adverse reactions of Compound Kushen Injection combined with Nedaplatin injected intrapleurally for patients with malignant pleural effusion. Methods ： A total of 72 patients with malignant pleural effusion was confirmed by histology or cytology of pleural fluid were randomly assigned to either control group or trial group. In the trial group, the patients were treated with Compound Kushen Injection （30 mL） plus 0.9% normal saline （50 mL1）, Nedaplatin （60 ,ng） and dexamethasone （10 mg） intrapleurallly, however, in the control group, the patients were treated with 0.9% normal saline （50 mL） ,Nedaplatin（60 mg） and dexamethasone（ 10 rag） intrapleurally. The cycle was repeated 5 to 7 days with the cycle re- peated for at most 4 times. The efficacy, quaIity of life and adverse drugreactions in the two groups were evaluated. Results ： The to- tal response rate was 86.1% in the trial group and that was 61.1% in the control group（P 〈0. 05）. The adverse reactions in the trial group were milder than those in the control group. Conclusion ： As compared with Nedaplatin alone, treatment of patients with malignant pleural effusion with Compound Kushen Injection improves both curative efficacy and patients＇quality of life.

关 键 词：复方苦参注射液 奈达铂 恶性胸腔积液 

分 类 号：R73[医药卫生—肿瘤]