扶正中药颗粒联合GC化疗方案对晚期非小细胞肺癌患者的免疫功能及近期疗效的影响分析  

Analysis of Immune Function and Short Term Efficacy in Patients with Advanced Nonsmall Cell Lung Cancer by Combination of Traditional Chinese Medicine Granule Combined with GC Chemotherapy

作　　者：蒋晓芳[1] 林山[1] 

机构地区：[1]武警浙江总队杭州医院肿瘤二科,浙江杭州310051

出　　处：《辽宁中医杂志》2017年第4期809-811,共3页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的:分析扶正中药颗粒联合盐酸吉西他滨和顺铂(GC)化疗方案对晚期非小细胞肺癌患者的免疫功能及近期疗效的影响。方法:选择从2013年6月—2016年6月来本院就诊的118例晚期非小细胞肺癌患者为研究对象。按照随机数表法,将118例患者平均分为中药组和对照组。中药组实施扶正中药颗粒联合GC化疗方案,对照组实施单纯GC方案。3周为1个治疗周期,连续治疗2个周期后,比较两组患者治疗前后免疫功能状态、近期疗效和不良反应情况。结果:治疗前两组患者的CD_3、CD_4、CD_8和NK无统计学差异(P>0.05)。中药组患者治疗后的CD_3、CD_4、CD_8和NK相比治疗前均下降,治疗前后差异具有统计学意义(P<0.05)。治疗后,中药组的CD_3、CD_4和NK值均高于对照组,两组患者免疫功能差异显著(P<0.05)。对照组总有效率为53.45%,中药组患者的总有效率为81.66%,中药组明显高于对照组,两组患者近期疗效差异明显(P<0.05)。对照组增加稳定率仅为56.90%,中药组增加稳定率为80.00%,明显高于对照组,两组患者Karnofsky评分变化差异显著(P<0.05)。对照组总不良反应率为5.00%(3/60),两组患者不良反应情况差异明显(P<0.05)。结论:扶正中药颗粒联合GC化疗方案治疗晚期非小细胞肺癌,患者免疫功能提高,近期治疗疗效,且临床症状得到有效缓解,生活质量明显改善。Objective：To analyze the Fuzheng Granule of Chinese medicine combined with gemcitabine and csplatin （GC） effects of chemotherapy on the immune function of patients with advanced nonsmall - cell lung cancer （NSCLC） and the recent curative effect. Methods：A total of 118 patients with advanced NSCLC in our hospital from June 2013 to June 2016 were selected as study subjects. According to the random number table method, the patients were divided into treatment group and control group. Traditional Chinese medicine group used the combination of Chinese medicine granule and GC chemotherapy regimen and the con- trol group used a simple GC program. Three weeks was a treatment cycle, 2 cycles of continuous treatment. We compared two groups＇ immune function status, short- term efficacy and adverse reactions before and after treatment. Results：There were no sig- nificant differences in NK,CD4,CDs and CD3 between the two groups before treatment （ P 〉 0. 05 ）. After treatment, the CD3 , CD4,CDs and NK in the traditional Chinese medicine group were decreased compared with before treatment,the difference was statistically significant （P 〈 0. 05）. After treatment, the CD3 , CD4 and NK values of the traditional Chinese medicine group were significantly higher than those in the control group, and the difference was significant between the two groups （ P 〈 0. 05 ）. The to- tal effective rate of control group was 53. d-5% and that of traditional Chinese medicine group was 81.66%. The traditional Chi- nese medicine group＇s was significantly higher than that of the control group and the short - term curative effect of the two groups was significantly different （ P 〈 0. 05 ）. The control group＇s increased stability rate was 56.90% and the traditional Chinese medi- cine group＇s increased stable rate was 80%, significantly higher than the control group＇s. The two groups had significant difference in Karnofsky score （P 〈 0. 05 ）. The total adverse reaction rate of control group was 5 %

关 键 词：扶正中药颗粒 GC化疗方案 非小细胞肺癌 晚期 免疫功能 疗效 

分 类 号：R734.2[医药卫生—肿瘤]