丙硫菌唑的工艺改进  

Process Improvement of Prothioconazole

作　　者：秦永其[1] QIN Yong-qi(Institute of Applied Chemistry, Lvliang University, Lvliang 033001, Shanxi, China)

机构地区：[1]吕梁学院应用化学研究所,山西吕梁033001

出　　处：《农药》2017年第4期250-252,共3页Agrochemicals

基　　金：吕梁市科技攻关项目(GG2015049)

摘　　要：[目的]对丙硫菌唑的合成路线进行优化,优化后的制备工艺更加简便、高效。[方法]以1-氯环丙基甲酸乙酯、邻氯苯乙酸乙酯和1-硫-3-氮杂环丁烷并[2,3,e]-1,2,4-三氮唑为原料,经过2步反应合成丙硫菌唑,优化条件下总收率达76.8%。[结果]目标化合物经~1H NMR光谱进行确认。[结论]该方法操作简单、反应条件温和、丙硫菌唑的收率高,适合工业化生产。[Aims] The synthesis process of prothioconazole is more simple and efficient after being optimized. [Methods] By the raw materials of ethyl 1-chlorocyclopropyl formate, ethyl chlorophenylacetate and 1-thio-3-azetidinyl [2,3,e]-1,2,4-triazole, the target compound is synthesized through two steps. Under the optimal conditions of the reaction, the total yield is 76.8%. [Results] The title compound is confirmed by 1H NMR spectroscopy. [Conclusions] The synthesis route of prothioconazole has the advantages of mild reaction condition, high yield and suitable industrial production.

关 键 词：丙硫菌唑 杀菌剂 合成 

分 类 号：TQ455.4[化学工程—农药化工]