血清AChE活性在急性胰腺炎病情及预后评估中的意义  

The significance of serum acetylcholinesterase activity in patients with acute pancreatitis and its relationship with disease severity and prognosis

作　　者：王俊[1] 冯志松[1] 凌颖[1] 江毅敏[1] 席春晖 

机构地区：[1]川北医学院附属医院消化内科,四川南充637007

出　　处：《胃肠病学和肝病学杂志》2017年第4期449-453,共5页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的探讨血清乙酰胆碱酯酶(acetylcholinesterase,ACh E)活性对急性胰腺炎(acute pancreatitis,AP)病情及预后评估的临床意义。方法收集2015年4月-2016年10月在川北医学院附属医院住院治疗的AP患者及同期健康体检者的临床资料,并采集研究对象入院时空腹血清以检测ACh E活性。分析影响ACh E活性的临床因素,采用受试者工作特征曲线分析ACh E活性与疾病严重程度及预后关系。结果与健康对照者比较,AP患者血清ACh E活性显著下降,与白蛋白含量呈明显负相关。当其值<8.05 IU/L时,其鉴别重症AP的敏感度和特异度分别是70.6%和90.0%,曲线下面积为0.786;当其值<6.8 IU/L时,预测死亡的敏感度和特异度分别是100%和93.0%,曲线下面积为0.978。结论血清ACh E活性可作为评估AP病情严重程度及预测死亡的生物标志物。Objective To investigate the significance of serum acetylcholinesterase （ACHE） activity in patients with acute pancreatitis （AP） and its relationship with disease severity and prognosis. Methods The clinic data of AP pa- tients and healthy controls were collected from Apr. 2015 to Oct. 2016 in the Affiliated Hospital of North Sichuan Medi- cal College. Fast serum was obtained in the morning after the admission day. Serum AChE activity was detected and its relationship with other clinical characteristics was analyzed. The correlation of AChE activity with disese severity and prognosis was analyzed by receiver operating characteristic （ROC） . Results Serum AChE activity of AP patients had declined compared with healthy controls. It was inversely correlated with serum albumin. Based on ROC curves, the optimal cut-off point was 8.05 IU/L for severe AP, and the sensitivity and specificity values were 70.6% and 90.0% , respectively. The optimal cut-off point was 6.8 IU/L for death, and the sensitivity and specificity values were 100% and 93.0% , respectively. Conclusion Serum AChE activity can be regarded as a remarkable biomarker for disease severi- ty and prognosis in AP patients.

关 键 词：乙酰胆碱酯酶 急性胰腺炎 受试者工作特征曲线 病情 预后 

分 类 号：R576[医药卫生—消化系统]