醒后卒中与进展性卒中的相关性研究  

Correlation of wake-up stoke with progressive stroke

作　　者：王建[1] 翟明锋 曹树刚[1] 葛婷婷[1] 贺军[1] 郭茜[1] 夏明武[1] 徐文安[1] 

机构地区：[1]合肥市第二人民医院神经内科,230011 [2]阜阳市人民医院神经内科,236006

出　　处：《中华神经医学杂志》2017年第4期398-401,共4页Chinese Journal of Neuromedicine

基　　金：合肥市科技局课题（合科[2014]71号）

摘　　要：目的探讨醒后卒中与进展性卒中的关系。方法选择自2014年1月至2015年12月合肥市第二人民医院神经内科收治的312急性脑梗死患者，依据是否出现卒中进展分为进展性卒中组（70例）和非进展性卒中组（242例），比较2组患者基本资料、临床特征以及醒后卒中的发生率，分析醒后卒中与进展性卒中的关系。结果与非进展性卒中组比较．进展性卒中组醒后卒中发生率（40．0％vs．18．2％）、同型半胱氨酸[（17．486±16．835）μmol／L vs（14.321±7.251）μmol／L]、纤维蛋白原[（3．539±1．009）g／L vs（3．134±0．775）g／L]显著增高，差异均有统计学意义（P〈0．05）。多因素Logistic回归分析显示醒后卒中（OR=2．978，95％CI：1．623～5．464，P=0．000）、同型半胱氨酸（OR=1．026，95％CI：1．002～1．052，P=0．035）、纤维蛋白原fOR=1．800，95％CI：1-310～2．472，P=0．000）是进展性卒中的独立危险因素。结论醒后卒中是进展性卒中的独立预测因素。Objective To study the correlation of wake-up stroke with progressive stroke. Methods Three hundred and twelve patients with acute ischemic stroke, admitted to our hospital from January 2014 to December 2015 were divided into progressive stroke group （n=70） and non-progressive stroke group （n=242）. Demographic features, clinical characteristics, and incidence of wake-up stroke were compared between the two groups. The association between wake-up stroke and progressive stroke was analyzed. Results The incidence of wake-up stroke, homocysteine level, and fibrinogen level in progressive stroke group were significantly higher than those in the non-progressive stroke group （40.0% vs. 18.2%, P=0.000; [17.486±16.835]μmol/L vs. [14.321±7.251] μmolJL, P=-0.023; [3.539±1.009] g/L vs. [3.134±0.775] g/L, P=0.000）. Multivariate Logistic regression analysis showed that wake-up stoke, homocysteine and fibrinogen were the independent predictive factors of progressive stroke （OR=2.978, 95%CI： 1.623-5.464, P=-0.000; OR=1.026, 95%CI： 1.002-1.052, P=0.035; OR=1.800, 95%CI： 1.310-2.472, P=0.000）. Conclusion Wake-up stoke is a predictive factor of progressive stroke.

关 键 词：醒后卒中 进展性卒中 预测因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]