利舒康胶囊治疗非痴呆性血管性认知功能障碍的效果  

Effects of capsule LI SHU KANG on the patients with not dementia vascular cognitive impairment

作　　者：李志军[1] 邹为[1] 唐娜[1] 杨渊[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院神经内科,武汉430030

出　　处：《中国临床保健杂志》2017年第2期158-161,共4页Chinese Journal of Clinical Healthcare

基　　金：教育部留学回国人员科研启动基金(教外司留[2014]1685号);华中科技大学院系自主创新研究基金资助(2016YXMS109)

摘　　要：目的观察利舒康胶囊治疗非痴呆性血管性认知功能障碍(VCIND)的临床疗效。方法通过简易智能精神状态量表(MMSE)和蒙特利尔认知评估量表(MoCA)选取126例VCIND患者为观察对象,随机数字表法平均分为利舒康组和对照组。比较治疗前后MMSE、MoCA评分总分和认知功能亚项以及血清超氧化物歧化酶(SOD)水平等变化。结果治疗前,两组VCIND患者血清SOD值较正常值明显减低(P<0.01),但两组间血清SOD值、MMSE和MoCA评分差异无统计学意义(P>0.05)。治疗后两组血清SOD值、MMSE及MoCA评分较治疗前均显著升高(P<0.05);与对照组相比,利舒康组改善更为显著(P<0.05)。对MoCA各认知功能亚项评分分析显示:与对照组相比,利舒康胶囊治疗组在提高VCIND患者视空间与执行力、注意力、延迟回忆以及抽象能力方面评分更明显(P<0.01)。结论利舒康胶囊具有抗氧化作用,能够改善VCIND患者认知功能。Objective To observe the effects of capsule LI SHU KANG on the patients with not dementia vas-cular cognitive impairment （ VCIND） . Methods One hundred and twenty-six patients of VCIND were randomly divided into control group and capsule LI SHU KANG group. The recognition of each group was assessed by the mini-mental state examination scale （MMSE） and Montreal cognitive assessment scale （MoCA） on the first day and 3 months later, as well as the super oxide dismutase （SOD） were measured in each group. Results The SOD were obviously decreased in both groups compared to normal control（P 〈0.01）. However,there were no significant differences between two groups before treatment in SOD,MMSE and MoCA scale （ P 〉 0. 05 ） . Serum SOD, MMSE and MoCA scale after treatment in both groups were significantly higher than those before treatment（P 〈0. 05） . Compared with the control group, the im- provment of SOD,MMSE and MoCA scale of patients in capsule LI SHU KANG group were more obvious（P 〈0.05）. The sub-domains of MoCA scale in the aspects of visuospatial abilities, executive functions, attention, short-term memory recall task and abstract were more obvious （ P 〈 0. 01 ） . Conclusions The capsule LI SHU KANG is effective to im-prove the recognition impairment of VCIND by antioxidant.

关 键 词：脑血管障碍 认知障碍 超氧化物歧化酶 中成药 

分 类 号：R749.1[医药卫生—神经病学与精神病学]