壳聚糖/海藻酸钠/活性肽复合膜的制备与性能研究  

Research on the preparation and properties of chitosan-alginate-activated-peptide composite films

作　　者：李楚燕 程瑜[1] 胡章[1] 杨萍[1] 廖铭能[1] 李思东[1] LI Chu-yan CHENG Yu HU Zhang YANG Ping LIAO Ming-neng LI Si-dong(Department of Applied Chemistry, College of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, Chin)

机构地区：[1]广东海洋大学化学与环境学院应用化学系,广东湛江524088

出　　处：《化学工程师》2017年第4期9-12,共4页Chemical Engineer

基　　金：广东省自然科学基金(2016A030308009);广东海洋大学"创新强校工程"项目(2015KTSCX053;GDOU2013050221)

摘　　要：以壳聚糖和海藻酸钠高分子为基质原料,采用层层自组装技术形成聚电解质复合多层膜,并包裹深海鱼蛋白活性肽,考察复合膜的厚度、溶胀度、透气性、抗拉伸强度、累积释放度等基本性能。结果表明,制备复合膜的最佳条件为壳聚糖(分子量50kDa)与海藻酸钠的质量分数比2∶1。在此条件下,制备复合膜层数为7层时,其厚度为0.041mm、透气性63.96%、溶胀度为179.92%,断裂拉伸率为12.45%,3h累计释放度为11.58%,显示出优越的生物医用膜性能,这将为开发一种新型的生物创伤医用膜提供参考。In order to prepare chitosan alginate-peptide composite films from chitosan and alginate, polyelectrolyte multilayer composite membranes were formed by layer-by-layer self-assembly technique and the fish protein peptides were packed. Basic properties of the composite membranes including thickness, degree of swelling, permeability, tensile strength and the accumulative release percentage were detected. The results showed that the optimum conditions were as follows： the mass ratio of chitosan （molecular weight 50kDa） and sodium alginate 2：1 and 7layers of the films. Under the conditions, the composite films were prepared with thickness 0.041 mm, swelling ratio 179.92%, permeability 63.96%, tensile rate 12.45% and the accumulative release percentage 11.58%. It will provide the references for developing a novel trauma biomedical membrane.

关 键 词：壳聚糖 海藻酸钠 活性肽 层层组装技术 创伤修复 

分 类 号：S667.1[农业科学—果树学]