产前牛磺酸干预生长受限患儿脑发育障碍的效果分析  

Effect of prenatal taurine intervention on the brain development in growth restriction fetus

作　　者：林伟斌[1] 

机构地区：[1]深圳市妇幼保健院新生儿科,广东深圳518082

出　　处：《现代医学》2017年第1期93-96,共4页Modern Medical Journal

摘　　要：目的:探讨产前牛磺酸干预生长受限胎儿脑发育障碍的效果。方法:选择2015年7月至2016年3月超声示胎儿生长受限的120例孕妇为研究对象。根据孕妇自愿原则将其分为对照组和观察组,观察组给予牛磺酸300 mg·(kg·d)-1治疗,比较两组新生儿磁共振弥散张量成像(DTI)参数各向异性分数、平均弥散系数、垂直弥散系数、平行弥散系数和血清TNF-α、IL-6、IL-8水平。结果:3个月后两组患儿全脑白质各向异性分数显著升高,观察组更明显,而两组新生儿平均弥散系数、垂直弥散系数、平行弥散系数、血清TNF-α、IL-6、IL-8水平均下降,观察组尤甚,差异均有统计学意义(P<0.05)。结论:牛磺酸能够显著促进生长受限胎儿脑发育,促进白质纤维发育及髓鞘化,有效降低患儿血清TNF-α、IL-6及IL-8水平,值得临床推广应用。Objective ： To explore the effect on the brain developmental disorders of the growth restriction fetus by prenatal taurine intervention. Methods ： 120 cases pregnant women with fetal growth restriction by ultrasound who were treated in our hospital from July 2015 to March 2016 were selected as the research objects, they were divided them into the observation group and the control group according to the . The neonatal DTI parameters of anisotropic scores, the average dispersion coefficient, the vertical dispersion coefficient, the parallel dispersion coefficient and serum TNF-a, IL-6, IL-8 levels of two groups were compared. Results ：After 3 months, the whole brain white matter anisotropic score of two groups increased significantly, tbservation group was more obvious（P〈0.05）.The average dispersion coefficient, the vertical dispersion coefficient, the parallel dispersion coefficient, serum TNF-a, IL - 6, IL - 8 level of two groups newborns decreased, the observation group was more obvious, there was statistically significant difference （P〈0.05）.Conclusion ： Prenatal taurine can significantly promote the growth restriction fetal brain development, it can promote the development of white matter fiber and myelin sheath, effectively reduce the patients＇ serum TNF-a, IL-6 and IL 8 levels in order to guide the choice of clinical treatment, it is worth popularization and application in clinic.

关 键 词：牛磺酸 生长受限 脑发育障碍 

分 类 号：R72[医药卫生—儿科]