胃癌组织中Vav1蛋白表达与胃癌临床生物学行为及预后的关系  

Expression of Vav1 protein in gastric cancer and it's relationship with clinical biological behaviors and prognosis of gastric cancer

作　　者：范立侨[1] 谭明[1] 李勇[1] 檀碧波[1] 王冬[1] 刘庆伟[1] 

机构地区：[1]河北医科大学第四医院外三科,河北石家庄050011

出　　处：《东南大学学报（医学版）》2017年第1期4-8,共5页Journal of Southeast University(Medical Science Edition)

基　　金：国家自然科学基金资助项目(81372580);河北省自然科学基金资助项目(H2016206173);河北省科技项目(14277779D)

摘　　要：目的:探讨胃癌组织中Vav1蛋白表达与肿瘤临床生物学行为及预后的关系,并对Vav1蛋白与转移相关蛋白MMP-2、TIMP-1的关系进行分析。方法:采用免疫组织化学方法检测Vav1、MMP-2、TIMP-1蛋白在胃癌及癌旁组织中的表达,收集患者的临床资料并进行随访。结果:Vav1、MMP-2蛋白在胃癌组织中的阳性表达率高于癌旁组织(均P<0.01),TIMP-1蛋白在胃癌组织中表达低于癌旁组织(P<0.01)。Vav1蛋白与肿瘤分化程度、浸润深度、淋巴结转移、TNM分期相关(P<0.05)。Vav1阳性表达患者5年生存率为26.26%,明显低于阴性表达患者(50.82%)(均P<0.05)。Cox比例风险回归显示,Vav1阳性表达是影响患者预后的独立危险因素(P<0.05)。Vav1与MMP-2存在正相关关系(P<0.05)。结论:Vav1与胃癌的侵袭转移有关,Vav1阳性表达是胃癌预后差的标志。Objective： To explore the relationship between the expression of Vavl protein and clinical biological behavior, prognosis of gastric cancer, and to analysize of the relationship among Vavl protein MMP-2 and TIMP-1 of the metastasis associated protein. Methods： Expressions of Vavl, MMP-2, TIMP- 1 proteins in gastric cancer and pa- racancerous tissues were tested by immunohistochemistry. Data of clinicopathological characteristics and follow-up were also collected. Results： The expressions of Vavl, MMP-2 in gastric cancer were higher than in paracancerous tissue（ all P 〈 0.01 ） ,whereas expression of TIMP-1 was lower in gastric cancer than in paracancerous tissues（ P 〈 0.01 ）. The expression of Vavl in gastric cancer was correlated with the tumor differentiation, tumor infiltration depth,lymph node metastasis and TNM stage （ all P 〈 0.05 ）. Five years survival rate in patients with Vavl positive was 26.26% , and the negative was 50.82% （ P 〈 0.05 ）. Cox proportional hazard regression showed that the positive expression of Vavl was an independent risk factor affecting the prognosis of patients （P 〈 0.05 ）. The expression of Vavl was positive correlated with MMP-2（ P 〈 0.05 ）. Conclusion： Vavl is involved in the invasion, metastasis of gastric cancer, and positive expression of Vav1 may be an independent risk factor for the prognosis of patients with gastric cancer.

关 键 词：胃癌 Vav1蛋白 侵袭 转移 预后 

分 类 号：R735.2[医药卫生—肿瘤]