基于生存分析对垂体瘤术后并发症相关因素的研究  

Analysis on the Postoperative Complications of Pituitary Adenoma based on Survival Analysis

作　　者：曹雪霞[1] 杨学瑜[2] 王立[1] 马雅辉[1] 穆志静[1] 孙丽娜[1] 修双玲[1] 

机构地区：[1]首都医科大学宣武医院内分泌科 [2]北京信息职业技术学院经济管理学院

出　　处：《中国病案》2017年第4期106-108,共3页Chinese Medical Record

摘　　要：目的以生存分析方法探讨垂体瘤术后并发症的发生时间以及其影响因素。方法选取垂体瘤手术的患者60例。应用有乘积限法估计发生术后并发症的生存时间,运用Cox比例风险模型进行多因素分析。结果 60例患者总体生存时间达498天,年龄和垂体瘤大小对生存时间的影响具有统计学意义,平均相对危险度分别1.062和1.018。统计结果显示,年龄和垂体瘤大小是独立的危险因素。结论年龄大和垂体瘤体积较大侵犯海绵窦或破坏鞍底均会增加术后并发症发生风险。Objective To estimate the survival time of the postoperative complications of pituitary adenoma（PA）and analyze the factors that may have impacts on it. Methods Data of 60 patients of pituitary adenoma were collected.The survival time of the postoperative complications of PA was estimated by the Kaplan-Meier method, and multi-factors analysis was conducted through a Cox model. Results The median survival time was 498 days. Age and size of PA effected the survival time, and their hazard degrees were 1.062 and 1.018, respectively. The results revealed that age and size of PA were independent risk factors. Conclusion Older age and larger size of PA may increase the risk of the postoperative complications of PA due to the PA＇s invading a patient＇s sious cavernosus or damaging the base of the sella.

关 键 词：垂体瘤 术后并发症 生存分析 生存时间 

分 类 号：R736.4[医药卫生—肿瘤]