中期因子在涎腺腺样囊性癌组织中的表达及意义  

Expression and significance of midkine in salivary adenoid cystic carcinoma

作　　者：李昀 孙沫逸 倪前伟 刘潇潇[2] 马超 赵振彦 高涛 任一雄 李欢 LI Yun SUN Moyi NI Qianwei LIU Xiaoxiao MA Chao ZHAO Zhenyan GAO Tao REN Yixiong LI Huan.(State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Disease, Shaanxi Clinical Research Center for Oral Disease, Department of Oral and Maxilofacial Surgery, School of Stomatology, Fourth Military Medical University, Xi＇ an 710032, China)

机构地区：[1]军事口腔医学国家重点实验室,口腔疾病国家临床医学研究中心,陕西省口腔疾病临床医学研究中心,第四军医大学口腔医院头颈肿瘤外科,陕西西安710032 [2]北京大学第一医院-丰台医院口腔科,北京100071

出　　处：《口腔医学》2017年第4期298-301,共4页Stomatology

基　　金：国家自然科学基金(30772428,81072230)

摘　　要：目的探讨中期因子(midkine,MK)在涎腺腺样囊性癌组织中的表达及其与发生嗜神经侵袭的关系。方法采用免疫组织化学SP法检测35例涎腺腺样囊性癌组织和20例正常涎腺组织中MK蛋白的表达情况,并分析其与嗜神经侵袭的关系。结果 MK在涎腺腺样囊性癌组织中高表达,阳性表达率为82.9%(29/35),在正常涎腺组织中低表达,阳性表达率为10.0%(2/20),二者间差异有统计学意义(P<0.01);MK的表达与患者的年龄、性别以及病理分型无关(P>0.05);与肿瘤是否发生嗜神经侵袭有关(P<0.05)。结论 MK蛋白可能参与涎腺腺样囊性癌的发生,其表达水平的升高可能与涎腺腺样囊性癌发生嗜神经侵袭有关。Objective To study the expression of midkine（MK） in salivary adenoid cystic carcinoma （SACC） and its relationship with perineural invasion（PNI）. Methods Immunohistochemistry staining （SP method） for MK was performed on 35 SACC and 20 normal salivary gland tissues（NSG）. Then, the correlation between the expression of MK and PNI was analyzed. Results In SACC, MK was highly expressed and the positive rate was 82.9% （29/35）while it was lowly expressed and the positive rate was 10.0% （2/20） in NSG, which showed significant difference （P〈0.01）. There was no relationship between the expression of MK and age, sex, pathologic types （P〉0.05）. However, there was significant difference between PNI cases and non-PNI cases（P〈0.05）. Conclusions MK may he associated with generation of SACC, and its overexpression may he contributed to the perineural invasion in SACC patients.

关 键 词：中期因子 涎腺腺样囊性癌 嗜神经侵袭 免疫组织化学 

分 类 号：R739.87[医药卫生—肿瘤]