PRP及PRP/OAM对种植体周围骨缺损修复的实验研究  

Experimental study of repair of bone defect around implant with PRP and PRP/OAM

作　　者：王毅[1] 刘杨[2] 杜军[1] 胡杨[3] WANG Yi LIU Yang DU Jun HU Yang(Department of Stomatology, Chinese Medicine Hospital Affiliated to Xinjiang Medical University, Urumqi 830000, Chin)

机构地区：[1]新疆医科大学附属中医医院口腔科,新疆乌鲁木齐830000 [2]新疆医科大学第六附属医院口腔科,新疆乌鲁木齐830002 [3]新疆医科大学第一附属医院口腔修复科,新疆乌鲁木齐830054

出　　处：《口腔医学》2017年第4期302-306,共5页Stomatology

基　　金：新疆维吾尔自治区自然科学基金(2014211C037)

摘　　要：目的探讨富血小板血浆(PRP)以及PRP复合骨诱导活性材料(PRP/OAM)对种植体周围骨缺损修复的作用。方法选取成年Beagle犬4只,体质量10~13 kg,每只犬左右两侧下颌第四前磨牙牙位随机分为A组和B组,与B组同侧的第一、二前磨牙牙位作为对照组。A组种植体周围骨缺损区植入PRP/OAM,B组植入PRP/磷酸三钙,对照组植入磷酸三钙。采用能谱分析各组种植体-新骨界面Ca^(2+)含量,同时观察各组种植术后8、16周组织学形态。结果 A组和B组种植术后8、16周时种植体部位骨表面Ca^(2+)含量均明显高于对照组(P<0.05);A组种植术后8、16周时种植体部位骨表面Ca^(2+)含量为(26.01±3.28)%和(44.10±7.11)%,明显高于B组(P<0.05);种植术后8周,A组新骨与种植体形成区段性骨结合,B组种植体边缘可有新骨形成,对照组种植体边缘为纤维性界面;种植术后16周,A组和B组新骨与种植体形成骨整合,对照组仅为纤维性结合。结论 PRP及PRP/OAM在种植体周围骨缺损修复中,能有效促进骨缺损修复。Objective To investigate the effect of rich platelet plasma （PRP） and PRP composite osteoinduction active material （PRP/OAM） on the repair of bone defect around implant. Methods Four adult Beagle dogs were selected which weight 10 - 13 kg, and each dog＇s left and right mandibular fourth molar teeth were randomly divided into group A and group B, the first and second molar teeth in the same side with group B as control group. In group A, bone defect around the implant was implanted with PRP/OAM, group B was implanted with PRP/calcium phosphate, and the control group was implanted with calcium phosphate. The contents of Ca2＋ on the implant bone interface of each group were analyzed by energy spectrum, and the histological patterns of 8 and 16 weeks after implantation were observed. Results Ca2＋ content on the planting body bone surface of group A and group B planting after 8 and 16 weeks was significantly higher than that of the control group （P〈 0.05 ） ; Ca2＋ content on the planting body bone surface of group A planting after 8, 16 weeks were （26.01 ± 3.28 ）% and （44.10 ± 7.11 ）%, which were significantly higher than that in group B （P〈 0.05 ） ; 8 weeks after implantation, in group A new hone and implant formed sectional osseointegration, in group B new bone formed at the implant edge, and the control group implant edge was fibrous interface; 16 weeks after implantation, in group A and group B new bone and implant formed bone integration, in the control group it was only fibrous combination. Conclusion PRP and PRP/OAM in the repair of bone defects around implants can effectively promote the repair of bone defects.

关 键 词：种植牙 骨缺损 富血小板血浆 骨诱导活性材料 犬 

分 类 号：R782.1[医药卫生—口腔医学]