眼底动脉硬化与脑梗死复发的关系研究  

Correlation of ocular fundus atherosclerosis with recurrence of cerebral infarction

作　　者：王竞男[1] 曹利民[1] 李红琴[1] 王建龙[1] 侯群[1] 

机构地区：[1]浙江中医药大学附属江南医院神经内科,杭州311200

出　　处：《浙江医学》2017年第7期545-548,共4页Zhejiang Medical Journal

基　　金：浙江省中医药科技计划项目(2015Z B0096)

摘　　要：目的探讨眼底动脉硬化与脑梗死复发的关系。方法选择71例因脑梗死住院的患者作为研究对象,根据头颅MRI检查结果将其分为脑梗死初发组36例,脑梗死复发组35例,并选取同期健康体检者34例作为正常对照组。比较3组高血压、糖尿病、心脏病及眼底动脉硬化的发生率,比较血糖、血脂水平,并分析眼底动脉硬化程度与脑梗死复发的关系及发生眼底动脉硬化的危险因素。结果脑梗死复发组的高血压、糖尿病、心脏病发生率(77.1%、40.0%、31.4%)均高于脑梗死初发组(69.4%、30.6%、25.0%)和正常对照组(61.8%、17.6%、8.8%),差异有统计学意义(均P<0.05)。脑梗死初发组、脑梗死复发组的FPG、TC[(5.89±2.21)、(5.30±0.84),(6.36±2.22)、(6.32±0.87)mmol/L]均高于正常对照组[(4.12±2.23)、(2.89±0.93)mmol/L],差异均有统计学意义(均P<0.01)。在脑梗死复发组中,各级眼底动脉硬化病变的发生率(91.4%、97.1%、88.1%、42.9%)均高于脑梗死初发组(83.3%、88.9%、69.4%、30.6%)和正常对照组[(82.4%、32.4%、2.9%、0],差异有统计学意义(P<0.05)。logistic回归分析显示,眼底动脉硬化Ⅲ级病变与脑梗死复发相关(P<0.05)。高血压、糖尿病是眼底动脉硬化的独立影响因素。结论眼底动脉硬化与脑梗死复发有关。Objective To investigate the correlation of ocular fundus atherosclerosis with the recurrence of cerebral infarction.Methods Seventy one patients with cerebral infarction were enrolled in the study.Based on MRI findings the patients were classified as incipient cerebral infarction（n=36） and recurrent cerebral infarction（n=35）,and 34 healthy subjects served as normal controls.The prevalence of hypertension,diabetes,heart disease,fundus atherosclerosis,and the blood glucose and lipids levels were compared among three groups.The correlation of fundus atherosclerosis with the recurrent cerebral infarction was analyzed,the risk factors of fundus atherosclerosis were also analyzed.Results The prevalence of hypertension,diabetes and heart disease in recurrent cerebral infarction group was significantly higher than that in incipient cerebral infarction group and normal control group（P 〈0.05）.The fasting plasma glucose（FPG）,TG,TC,HDL-C,LDL-C levels in incipient group were significantly lower than those in recurrent group（P 〉 0.05）.The FPG and TC levels in cerebral infarction patients were higher than those in normal control group（P〈 0.01）.In the recurrent cerebral infarction group,the prevalence of ocular fundus arteriosclerosis disease of all grades were higher than that in incipient cerebral infarction group and normal control group（P〈0.05）.Logistic regression analysis showed that the recurrence of cerebral infarction was associated with fundus atherosclerosis grade Ⅲ;and also showed that high blood pressure,diabetes were independent risk factors of ocular fundus atherosclerosis.Conclusion The recurrence of cerebral infarction is correlated with ocular fundus atherosclerosis.

关 键 词：眼底动脉硬化 脑梗死复发 危险因素 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R77[医药卫生—临床医学]