重组人内皮抑素持续泵注联合TP化疗对晚期卵巢癌患者血清恶性分子、血管新生分子的影响  

Effect of continuous recombinant human endostatin pumping combined with TP chemotherapy on serum malignant molecules and angiogenesis molecules in patients with advanced ovarian cancer

作　　者：陈卫东 

机构地区：[1]湖北省武汉市新洲区中医医院,湖北武汉430400

出　　处：《海南医学院学报》2017年第5期613-616,共4页Journal of Hainan Medical University

基　　金：武汉市科技局一般项目(20140815)~~

摘　　要：目的:研究重组人内皮抑素持续泵注联合TP化疗对晚期卵巢癌患者血清恶性分子、血管新生分子的影响。方法:选择2011年7月~2015年12月间在本院接受治疗的晚期卵巢癌患者78例,按照单盲随机对照法分为观察组、对照组各39例。治疗前、治疗4周期后,采用电化学发光免疫分析仪检测血清肿瘤标志物含量;采用放射免疫法检测血清凋亡分子含量;采用酶联免疫吸附法(ELISA)检测血清血管新生分子含量。结果:治疗前,两组患者的血清肿瘤标志物、凋亡分子、血管新生分子含量差异无统计学意义(P>0.05)。治疗4周期后,观察组患者血清中CA125、CA153、HE4、CEA、β-HCG、Bcl-2、Survivin、Bag-1、Ang-2、VEGF、bFGF的含量均显著低于对照组患者,Bax的含量显著高于对照组患者。结论:重组人内皮抑素持续泵注联合TP化疗可降低晚期卵巢癌恶性程度,抑制血管新生。Objective：To study the effect of continuous recombinant human endostatin pumping combined with TP chemotherapy on serum malignant molecules and angiogenesis molecules in patients with advanced ovarian cancer.Methods：A total of 78 patients with advanced ovarian cancer who were treated in our hospital between July 2011 and December 2015 were selected and divided into observation group and control group（n=39）according to the single-blind randomized control method.Before treatment and after 4cycles of treatment,electrochemical luminescence immunity analyzer was used to detect serum tumor marker levels;RIA method was used to determine serum apoptosis molecule levels;enzyme-linked immunosorbent assay（ELISA）was used to detect the serum angiogenesis molecule levels.Results：Before treatment,differences in serum levels of tumor markers,apoptosis molecules and angiogenesis molecules were not statistically significant between two groups of patients（P〉0.05）.After 4cycles of treatment,serum CA125,CA153,HE4,CEA,β-HCG,Bcl-2,Survivin,Bag-1,Ang-2,VEGF and bFGF levels of observation group were significantly lower than those of control group while Bax level was significantly higher than that of control group.Conclusions：Continuous recombinant human endostatin pumping combined with TP chemotherapy can decrease the malignant degree of advanced ovarian cancer and inhibit angiogenesis.

关 键 词：晚期卵巢癌 重组人内皮抑素 肿瘤标志物 血管新生 

分 类 号：R737.31[医药卫生—肿瘤]