小动脉硬化性脑小血管病与睡眠障碍  

Arteriosclerotic cerebral small vessel diseases and sleep disturbances

作　　者：张苗怡 唐杰[1] 付建辉[1] 

机构地区：[1]复旦大学附属华山医院神经内科,上海200040

出　　处：《国际脑血管病杂志》2017年第2期165-169,共5页International Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金（81671151）

摘　　要：研究显示，脑小血管病可通过脑组织损害影响神经回路、局部脑血流量改变及神经内分泌改变等机制造成睡眠障碍，且脑小血管病所致的卒中后抑郁和脑萎缩均可能与睡眠障碍有关。反过来，睡眠障碍可损害血脑屏障和脑血管自动调节功能，增高脑小血管病的发病风险。两者相互联系，互为因果，共同影响患者预后和生存质量。Studies have shown that cerebral small vessel diseases can affect the mechanisms such as neural circuits, local cerebral blood flow changes, and neuroendocrine changes through brain damage, causing sleep disorders, and poststroke depression and brain atrophy caused by cerebral small vessel diseases may be associated with sleep disorders. In return, sleep disorders can damage the blood-brain barrier and cerebrovascular autoregulation function, and increase the risk of the occurrence of cerebrovascular disease. Both of them are interrelated, reciprocal causation, and commonly affect the prognosis and quality of life in patients.

关 键 词：脑小血管疾病 颅内动脉硬化 睡眠 睡眠呼吸暂停 阻塞性 睡眠障碍 睡眠呼吸暂停综合征 睡眠觉醒障碍 危险因素 

分 类 号：R740[医药卫生—神经病学与精神病学] R743[医药卫生—临床医学]