缺血缺氧性脑病新生儿的神经行为评分与血浆神经肽Y水平的相关性  

Relationship between neurological behavior score and plasma level of neuropeptide Y in neonates with hypoxic ischemic encephalopathy

作　　者：李岩[1] 雷勋明[1] 李霞[2] 

机构地区：[1]湖北医药学院附属东风医院儿科,湖北十堰442000 [2]湖北医药学院附属东风医院眼科,湖北十堰442000

出　　处：《中国临床神经外科杂志》2017年第4期228-230,共3页Chinese Journal of Clinical Neurosurgery

基　　金：湖北省教育厅科学研究计划项目(B2014049)

摘　　要：目的探讨缺血缺氧性脑病(HIE)新生儿的神经行为评分与血浆神经肽Y水平的相关性。方法选取62例HIE新生儿作为观察组,另选取60例相同出生日龄的健康新生儿作为对照组。采用新生儿神经行为量表(NBNA)测定神经行为评分,利用放射免疫分析法检测血浆神经肽Y水平。结果观察组NBNA评分[(34.01±0.64)分]显著低于对照组[(38.92±0.71)分;P<0.05],血浆神经肽Y水平[(192.74±13.62)ng/L]显著高于对照组[(65.75±10.01)ng/L;P<0.05)。治疗后,HIE新生儿NBNA评分[(37.43±0.82)分]显著高于治疗前[(34.01±0.64)分;P<0.05],血浆神经肽Y水平[(74.45±9.82)ng/L]显著低于治疗前[(192.74±13.62)ng/L;P<0.05)。HIE新生儿NBNA评分与血浆神经肽Y表达水平呈明显负相关(r=-0.527,P<0.05)。结论与正常新生儿相比,HIE新生儿的神经行为评分与血浆神经肽Y水平存在明显异常,且二者具有明显负相关。Objective To investigate the relationship between the neurological behavior score and the plasma level of neuropeptide Y in the neonates with hypoxic ischemic encephalopathy （HIE）. Methods The neurological behavior scores and plasma levels of neuropeptide Y were determined respectively by the neonatal behavioral neurological assessment （NBNA） and radioimmunoassay in 62 neonates with HIE （observed group） and 62 healthy neonates （control group）. The outcomes were compared between both the groups. The relationship of NBNA scores with plasma levels of neuropeptide Y was analyzed by Pearson related model. Results NBNA scores [（34.01±0.64） points] were significantly lower in the observed group before the treatment than those [（38.92±0.71） points] in the control group （P〈0.05）. The plasma level of neuropeptide Y [（192.74±13.620）ng/L] was significantly higher in the observed group before the treatment than that [（65.75±10.00）ng/L] in the control group （P〈0.05）. The NBNA scores [（37.43±0.82） points] were significantly higher after the treatment than those before the treatment in the observed group （P〈0.05）. The plasma level of neuropeptide Y [（74.45±9.82）ng/L] was significantly lower after the treatment than that before the treatment in the observed group （P〈0.05）. The neonatal Pearson model analysis showed that NBNA score was negatively related to the plasma level of neuropeptide Y in the observed group （r=-0.527, P〈0.05）. Conclusions The neurological behavior score and the plasma level of neuropeptide Y are significantly abnormal in the neonates with HIE compared to those in the healthy newborns. There is significant negative correlation between NBNA score and plasma level of neuropeptide Y.

关 键 词：缺血缺氧性脑病 新生儿 神经行为 神经肽Y 血浆 相关性 

分 类 号：R742.3[医药卫生—神经病学与精神病学]