8-羟基脱氧鸟苷在氧化应激与儿童相关疾病的研究  

Research progress of 8-hydroxy-2′-deoxyguanosine in oxidative stress and childhood-related diseases

作　　者：黄希[1] 彭文涛[1] 罗碧如[1] 

机构地区：[1]四川大学华西第二医院儿科、出生缺陷与相关妇儿疾病教育部重点实验室,成都610041

出　　处：《中华妇幼临床医学杂志（电子版）》2017年第2期144-148,共5页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：国家临床重点专科建设项目(131120003303);四川省科技厅科技支撑项目(14ZC1796)~~

摘　　要：8-羟基脱氧鸟苷(8-OHdG)是DNA氧化损伤产物之一。8-OHdG水平可反映机体氧化损伤程度,是目前国际上公认的评价DNA氧化损伤和氧化应激(OS)状态的新型指标和生物标志物。笔者拟就8-OHdG的主要检测方法及其在OS与儿童相关疾病的最新研究进展进行阐述,旨在为临床对该类疾病的诊断与治疗提供参考依据。As we know, 8-hydroxy-2′-deoxyguanosine （8-OHdG） is one of the oxidative damage products of DNA. The level of 8-OHdG can reflect the degree of oxidative damage in the body, and it is recognized internationally as one of new indicators and biomarkers for evaluating DNA oxidative damage and oxidative stress （OS） state. This study will focus on the detection method of 8-OHdG, and the research progress of 8-OHdG in OS and childhood-related diseases, in order to provide a reference for the diagnosis and treatment of those disease.

关 键 词：8-羟基脱氧鸟苷 DNA氧化损伤 生物学标记 儿童 

分 类 号：R363[医药卫生—病理学]