慢性胃炎患者血清PG变化及临床意义  

Change and clinical significance of serum PG in patients with chronic gastritis

作　　者：桓伟华[1] 黄芳[1] 贾正艳 刘印桐 

机构地区：[1]河北省沧州市青县人民医院,河北沧州062650

出　　处：《海南医学院学报》2017年第6期749-751,共3页Journal of Hainan Medical University

基　　金：沧州市科学技术项目(162302135)~~

摘　　要：目的:观察慢性萎缩性胃炎(CAG)患者血清胃蛋白酶原(PG)的变化及临床意义。方法:采用双抗体夹心酶联免疫吸附法对我院收治并确诊为CAG、胃息肉、胃癌患者外周血PG水平进行检测,并与同期来院体检正者进行对比,观察PG在各类胃病患者外周血中的水平变化。结果:胃炎组血清PGⅠ表达及PG I/PGⅡ比值明显低于息肉组及对照组(P<0.05),但高于胃癌组(P<0.05),PGⅡ表达明显高于息肉组及对照组(P<0.05),但低于胃癌组(P<0.05);息肉组PGⅠ表达及PG I/PGⅡ比值明显高于胃炎组及胃癌组(P<0.05),PGⅡ表达明显低于胃炎组及胃癌组(P<0.05);胃癌组PGⅠ表达及PG I/PGⅡ比值均明显低于另外3组(P<0.05),PGⅡ表达均明显高于另外3组(P<0.05);胃炎组及胃癌组HP感染阳性患者血清PGⅠ表达均明显高于HP感染阴性患者(P<0.05),但PG I/PGⅡ比较无统计学差异(P>0.05);胃炎组HP感染阴性及感染阳性患者血清PGⅠ表达及PG I/PGⅡ比值均高于胃癌组HP感染阴性及感染阳性患者(P<0.05);血清PGⅡ表达均明显低于胃癌组(P<0.05)。结论:PG I表达及PG I/PGⅡ比值在CAG患者血清中明显下降,PG II表达明显增强,但PG I表达及PG I/PGⅡ比值仍明显高于胃癌患者,PG II表达则明显低于胃癌患者,在临床治疗中应注该指标变化,如PG I表达及PG I/PGⅡ比值明显下降,PG II表达明显增强,应注意病情恶化的可能。Objective： To observe the change and clinical significance of serum PG in patients with chronic atrophic gastritis （CAG）. Methods： ELISA was used to detect the peripheral blood PG level in patients confirmed with CAG, gastric polyps, and gastric cancer who were admitted in our hospital from January, 2015 to January, 2016. The normal individuals who came for physical examinations were served as the control group. The peripheral blood PG level in patients with various gastric diseases was observed. Results： The serum PG Ⅰ expression and PG Ⅰ/ PG Ⅱ in the gastritis group were significantly lower than those in the gastric polyps group and control group （P 〈0.05）, but were significantly higher than those in the gastric cancer group （P〈0.05） ; while PG Ⅱ expression was significantly higher than that in the gastric polyps group and control group （P〈0.05）, hut was significantly lower than those in the gastric cancer group （P〈0.05）. PG Ⅰ expression and PG Ⅰ/ PG Ⅱ in the gastric polyps group were significantly higher than those in the gastritis group and gastric cancer group （P0.05） ,while PG Ⅱ expression was significantly lower than that in the gastritis group and gastric cancer group （P〈0.05）. PG Ⅰ expression and PG Ⅰ/ PGⅡ in the gastric cancer group were significantly lower than those in the other three groups （P〈 0.05） ,while PGⅡ expression was significantly higher than that in the other three groups （P〈0.05）. The serum PG Ⅰ expression in patients with positive HP infection in the gastritis group and gastric cancer group was significantly higher than that in patients with negative HP infection （P〈0.05）, but the comparison of PG Ⅰ/ PG Ⅱ was not statistically significant （P〉 0.05）.The serum PG Ⅰ expression and PG Ⅰ/ PG Ⅱ in patients with negative and positive HP infection in the gastritis group were significantly higher than those in patients with negative and positive HP infection in the gastric cancer group （P〈0

关 键 词：HP CAG PG 表达 胃癌 

分 类 号：R573.3[医药卫生—消化系统]