血栓弹力图与急性脑梗死后出血性转化的相关性研究  

Correlative study on thrombelastogram and hemorrhagic transformation after acute ischemic stroke

作　　者：陈彦如[1] 罗海彦[1] 

机构地区：[1]重庆医科大学附属第二医院神经内科,重庆400010

出　　处：《国际检验医学杂志》2017年第8期1040-1042,共3页International Journal of Laboratory Medicine

基　　金：重庆市集成示范计划项目(cstc2015jcsf10006)

摘　　要：目的探讨急性脑梗死后血栓弹力图(TEG)各项指标与出血性转化(HT)的相关性。方法收集该院2016年1-11月收治的急性脑梗死未接受早期再灌注治疗的患者,分为HT组与非HT组。回顾性分析两组患者一般临床资料及TEG指标,进行组间比较和Logistic回归分析。结果共纳入患者71例,HT组11例。HT组大面积脑梗死、心源性栓塞比例均高于非HT组,且差异有统计学意义(P<0.05),凝血综合指数(CI值)低于非HT组,且差异有统计学意义(P<0.05);Logistic回归分析显示,大面积脑梗死(OR=13.172,95%CI:1.414~122.671)、CI值(OR=0.554,95%CI:0.321~0.956)与HT独立相关(P<0.05)。结论 CI值与急性脑梗死后HT的发生具有独立相关性,具有预测HT的潜力。Objective To investigate the correlation between indexes of thrombelastogram（TEG）and hemorrhagic transformation（HT）after acute ischemic stroke.Methods The cases of acute ischemic stroke but not receiving early reperfusion therapy were recruited in our hospital from January to November 2016,and were divided into HT group and non-HT group.Their general clinical characteristics and TEG indexes were retrospectively analyzed,and comparison between two groups and multivariate Logistic regression analysis were performed.Results A total of 71 cases were enrolled and 11 of them were divided into HT group.The percentages of massive cerebral infarction and cardio-embolic stroke were significantly higher in HT group than those in non-HT group（P〈0.05）,whereas the levels of CI in HT group were significantly lower than thoes in non-HT group（P〈0.05）.Multivariate Logistic regression analysis showed that massive cerebral infarction（OR=13.172,95%CI：1.414-122.671）and CI（OR=0.554,95%CI：0.321-0.956）were independently correlated with HT（P〈0.05）.Conclusion CI is independently correlated with HT after acute ischemic stroke,and may be a potential predictor of HT.

关 键 词：脑梗死 出血性转化 血栓弹力图 危险因素 

分 类 号：R743.33[医药卫生—神经病学与精神病学]