两种新型氧钒配合物的合成及抗肿瘤活性研究  

Synthesis and Antitumor Activities of Two Novel Oxovanadium(Ⅳ) Complexes

作　　者：叶振锋[1] 严高剑[1] 张咏莉[2] 柴栋[2] 陆家政[1] 

机构地区：[1]广东药科大学药学院,广东广州510006 [2]广东药科大学基础学院,广东广州510006

出　　处：《广州化工》2017年第8期88-90,126,共4页GuangZhou Chemical Industry

基　　金：广东省科技计划项目(No.2012B031800431和No.2013B031800018);广东药科大学科技处与附属医院联合基金(No.2014-36)

摘　　要：设计合成了两种含偶氮Schiff碱配体的新型氧钒配合物,采用元素分析、IR、ESI-MS H^1 NMR等方法表征和确证了配合物的结构。采用MTT法考察其对Hela和A549肿瘤细胞的增殖影响。结果显示,这两种配合物对Hela和A549肿瘤细胞均具有较好的抑制作用,且对Hela细胞更为敏感。此外,运用流式细胞术对药物作用后细胞的凋亡率及周期分布情况进行了检测,以进一步考察配合物抗肿瘤的作用机制,结果表明,[VO(MAST)(BrPIP)]可以阻滞肿瘤细胞分裂周期的G1期并且诱导Hela细胞早期凋亡。Two novel oxovanadium complexes containing azo Schiff base ligand were synthesized and characterized by elemental analysis, IR, ESI-MS and 1H NMR. Their anti-tumor activity toward Hela and A549 tumor cell lines were investigated by MTT assay. The results showed that these two complexes exhibited good potent antitumor activity. In addition, flow cytometry was used to detect the apoptosis rate and cycle distribution of the cells after drug treatment. It turned out that [ VO（MAST）（BrPIP）] could block the G1 phase of Hela cells and induce early apoptosis.

关 键 词：SCHIFF碱 钒配合物 抗肿瘤 

分 类 号：R914.3[医药卫生—药物化学]