促性腺激素释放激素受体在乳腺癌组织中的表达及其临床意义  

Expression of gonadotropin releasing hormone receptor in breast cancer tissue and its clinical significance

作　　者：陈玲[1] 何菁[1] 孟东[1] 孙春雷[1] 时伟锋[1] 齐晓薇[2] 金琳芳[2] 徐闻欢[3] 周士福[1] 

机构地区：[1]江南大学附属医院普外科,江苏无锡214062 [2]江南大学附属医院病理科,江苏无锡214062 [3]江南大学附属医院肿瘤内科,江苏无锡214062

出　　处：《中华乳腺病杂志（电子版）》2017年第2期74-77,共4页Chinese Journal of Breast Disease(Electronic Edition)

基　　金：国家自然科学基金青年科学基金资助项目(81402487);江苏省自然科学基金青年基金资助项目(BK20140170)

摘　　要：目的探讨促性腺激素释放激素受体(GnRH-R)在乳腺癌组织中的表达及其与患者临床病理特征的相关性。方法收集了2008年1月至2010年12月江南大学附属医院保存的104例浸润性乳腺导管癌患者的手术切除标本进行回顾性分析。应用免疫组织化学SP法观察乳腺癌组织中GnRH-R的表达,研究GnRH-R与乳腺癌患者临床病理特征之间的关系,并采用χ~2检验进行统计分析。结果乳腺癌组织中GnRH-R的阳性表达率为66.3%(69/104)。GnRH-R的阳性表达率在luminal A型、luminal B型、HER-2过表达型、三阴性乳腺癌患者中分别为5/11、61.4%(27/44)、8/16、87.9%(29/33),差异有统计学意义(χ~2=11.407,P<0.050)。两两比较显示,GnRH-R在三阴性乳腺癌的阳性表达率高于luminal A型(χ~2=8.455,P<0.008)和HER-2过表达型(χ~2=8.361,P<0.008)。乳腺癌组织中GnRH-R的阳性表达率在不同年龄、组织学分级、淋巴结转移状态及临床分期的患者中,差异没有统计学意义(χ~2=0.506,P=0.477;χ~2=0.007,P=0.936;χ~2=2.158,P=0.340;χ~2=0.007,P=0.936)。结论 GnRH-R在三阴性乳腺癌组织中呈高表达,可能为三阴性乳腺癌患者的治疗提供参考。Objective To investigate the expression of gonadotropin releasing hormone receptor （GnRH-R） in breast cancer tissue and its correlation with patients＇ clinicopathological characteristics. Methods We collected surgically resected specimens from 104 cases of invasive ductal breast cancer in the Affiliated Hospital of Jiangnan University from December 2010 to January 2008 for a retrospective study. The expression of GnRH-R in breast cancer tissue was detected by immunohistochemical SP method. The correlation between GnRH-R expression and patients＇ clinicopathological characteristics was analyzed using χ^2 test. Results The positive rate of GnRH-R in invasive breast cancer tissue was 66. 3% （69/104）. With regards to different molecular subgroups, the positive rate of GnRH-R was 5/11 in luminal A subtype, 61.4% （27/44）in luminal B subtype, 8/16 in HER-2 overexpression subtype and 87. 9% （29/33）in triple negative subtype, indicating a significant difference（χ^2= 11. 407, P〈0. 050）. The pairwise comparison showed that the positive expression rate of GnRH-R in triple negative subtype was significantly higher than that in luminal A subtype （ χ^2 = 8.455, P〈0. 008 ） or HER-2 overexpression subtype（χ^2 = 8. 361, P〈0. 008 ） respectively. The positive rates of GnRH-R in breast cancer tissues presented no significant difference in patients with different ages, histological grade, lymph node metastasis and clinical stages （χ^2 = 0. 506, P = 0. 477 ;χ^2 = 0. 007, P = 0. 936 ; χ^2 = 2. 158, P= 0. 340 ; χ^2 = 0. 007, P = 0. 936 ）. Conclusion GnRH-R is highly expressed in triple negative breast cancer tissue, which may provide references for the treatment of triple negative breast cancer.

关 键 词：乳腺肿瘤 分子分型 受体 GNRH 

分 类 号：R737.9[医药卫生—肿瘤]