血清维生素D水平在外周T细胞淋巴瘤患者预后中的意义  

Significance of the serum vitamin D level in evaluating the prognosis of patients with peripheral T-cell lymphoma

作　　者：董毅[1] 朱太岗[1] 李月红[1] 张飞虎[1] 夏瑞祥[2] 

机构地区：[1]蚌埠医学院第三附属医院皖北煤电集团总医院血液科,安徽宿州234011 [2]安徽医科大学第一附属医院血液科,安徽合肥230011

出　　处：《蚌埠医学院学报》2017年第2期167-169,共3页Journal of Bengbu Medical College

基　　金：安徽省科技厅基金项目(12010402c195)

摘　　要：目的:探讨血清维生素D在外周T细胞淋巴瘤(peripheral T-cell lymphoma,PTCL)中的表达水平及临床意义。方法:选取51例初诊PTCL患者(初治组)及正常健康人(对照组)20名,采用化学发光法测定血清25-羟基维生素D[25(OH)D]的表达水平。结果:PTCL患者血清25(OH)D的表达在初治组为20.110 ng/m L,低于对照组的48.812 ng/m L(P<0.01)。初治PTCL患者血清25(OH)D的表达水平与疗效呈正相关关系(P<0.05),与分期、国际预后指数评分呈负相关关系(P<0.01)。结论:监测血清25(OH)D的表达水平有助于非霍奇金淋巴瘤的疗效及预后评定。Objective： To detect the serum vitamin D level in patients with peripheral T-cell lymphoma （PTCL）, and its clinical significance. Methods： Fifty-one newly diagnosed PTCL patients and 20 healthy people were divided into the newly diagnosed group and control group, respectively. The serum expression levels of 25-hydroxy vitamin D ~ 25 （OH） D ] in two groups was determined by chemil method. Results：The level of 25 （OH）D in newly diagnosed group（20.110 ng/mL） was lower than that in control group （48.812 ）ng/mL （P 〈 0.01 ）. The serum level of 25 （OH） D in newly diagnosed group was positive correlation with the therapeutic efficacy（ P 〈 0.05 ）, and negative correlation with the clinical stage and IPI score （P 〈 0.01 ）. Conclusions：The level of 25 （OH）D is useful in estimating the therapeutic efficacy and prognosis in patient with PTCL.

关 键 词：淋巴瘤 血清25-羟基维生素D 预后 

分 类 号：R733.1[医药卫生—肿瘤]