EB病毒潜伏膜蛋白2A在胃癌中的表达及与预后的关系  

Expression of epstein-barr virus LMP2A in gastric cancer and its prognostic value

作　　者：孔庆丽[1] 谭桂艳[1] 韩磊[1] 杨东[1] 王军业[1] 

机构地区：[1]济宁医学院附属医院肿瘤科,山东济宁272029

出　　处：《临床肿瘤学杂志》2017年第3期219-222,共4页Chinese Clinical Oncology

基　　金：济宁市科技发展计划项目(2013jnwk59)

摘　　要：目的探讨EB病毒潜伏膜蛋白2A(LMP2A)在胃癌组织中的表达及其与预后的关系。方法免疫组织化学染色检测100例胃癌及癌旁组织中LMP2A的表达情况,并分析LMP2A蛋白表达与胃癌患者临床病理特征的关系;Kaplan-Meier方法绘制生存曲线,分析76例随访患者LMP2A表达与患者总生存期(OS)、无进展生存期(PFS)的关系。结果LMP2A在癌旁组织中几乎不表达,在胃癌组织中高表达,高表达率为47.0%(47/100);LMP2A高表达与胃癌的淋巴管浸润、血管浸润、临床分期有关(P<0.05);LMP2A高表达组的中位OS和PFS分别为52.0个月(95%CI:43.8~60.2个月)和47.0个月(95%CI:32.9~61.1个月),而LMP2A低表达组的中位OS和PFS均未达,差异均有统计学意义(P<0.05)。结论LMP2A在胃癌组织中高表达,其可能在胃癌的发生和进展中起重要作用。Objective To investigate the expression of epstein-barr virus latent membrane protein 2A （LMP2A） in gastric cancer tissues and its correlation with elinicopathological parameters and prognosis. Methods LMP2A expression in 100 cases of gastric cancer tissues and paracaneerous tissues was detected using immunohistochemistry. The correlation of LMP2A with clinical parame- ters was analyzed. The survival curves were drawn using Kaplan-Meier method and the correlation of LMP2A with overall survival（OS） and progression free survival（PFS） was analyzed in followed-up 76 patients. Results There was nearly no expression of LMP2A in pa- raeaneerous tissue. High expression of LMP2A was detected in gastric cancer tissues and the high expression rate was 47.0% （ 47/ 100）. High LMP2A expression was positively correlated with lmphytie invasion, vessel invasion and advanced clinical stage （P〈0.05）. The median OS and PFS of high LMP2A expression group was 52. 0 （95% CI：43.8-60. 2） months and 47.0 months （95% CI：32. 9- 61. 1 ）, respectively. The median OS and PFS of low LMP2A expression group were not reached. There was significantly statistical difference between both groups（P〈0. 05）. Conclusion LMP2A was high expressed in gastric cancer. It may play an important role in the development of gastric cancer.

关 键 词：胃癌 EB病毒 潜伏膜蛋白2A 预后 

分 类 号：R735.2[医药卫生—肿瘤]