结肠癌组织中Capn4和Ki-67的表达及临床意义  

Expression of Capn4 and Ki-67 in colon cancer and its clinical significance

作　　者：王东华[1] 贾喜花[1] 郑淑君[1] 赵霞[1] 张丙信[1] 王晓博[1] 

机构地区：[1]保定市第一中心医院肿瘤内科,河北保定071000

出　　处：《临床肿瘤学杂志》2017年第3期223-226,共4页Chinese Clinical Oncology

摘　　要：目的探讨钙蛋白酶小亚基-1(Capn4)和细胞核增殖指数(Ki-67)在结肠癌中的表达及其临床意义。方法采用免疫组化方法检测70例结肠癌及35例癌旁正常组织中Capn4和Ki-67的表达,并分析Capn4和Ki-67的表达与结肠癌临床病理特征的关系。结果 Capn4和Ki-67在结肠癌组织中的阳性表达率分别为74.3%(52/70)和84.3%(59/70),明显高于癌旁正常组织的22.9%(8/35)和17.1%(6/35),差异有统计学意义(P<0.05)。Capn4、Ki-67在结肠癌中的表达与浸润深度、TNM分期及淋巴结转移密切相关(P<0.05),而与年龄、性别、分化程度无关(P>0.05)。Capn4与Ki-67在结肠癌中的表达呈正相关(r=0.734,P<0.05)。结论 Capn4和Ki-67在结肠癌组织中高表达,可能与结肠癌的发生发展有关。Objective To investigate the expression of calpain small subunit-1 （Capn4） and nuclear proliferation marker（ Ki- 67） in colon cancer and its clinical significance. Methods Immunohistochcmieal method was used to detect the expression of Capn4 and Ki-67 in 70 cases of colon cancer and 35 cases of adjacent normal tissues. The relationship between the expression of Capn4 and Ki-67 and the clinicopathological features of colon cancer was analyzed. Results The positive expression rates of Capn4 and Ki-67 in colon cancer tissues were 74. 3% （52/70） and 84. 3% （59/70） , which were significantly higher than 22. 9% （ 8/35 ） and 17. 1% （ 6/ 35 ） of adjacent normal tissues, and the difference was statistically significant（ P〈0. 05 ）. The expression of Capn4 and Ki-67 was close- ]y related to the depth of invasion, TNM stage and lymph node metastasis（P〈0. 05） , which was not related with age, sex and differen- tiation degree（ P〉0. 05）. The expression of Capn4 was positively correlated with Ki-67 in colon cancer tissues （r = 0. 734, P〈0. 05）. Conclusion Capn4 and Ki-67 are highly expressed in colon cancer, and may be related to the occurrence and development of colon cancer.

关 键 词：结肠癌 Capn4 KI-67 免疫组化染色 

分 类 号：R735.3[医药卫生—肿瘤]