多巴胺联合酚妥拉明治疗小儿重症肺炎合并心衰疗效研究  

Clinical Efficacy of Dopamine Combined with Phentolamine in Treatment of Children with Serious Pneumonia Complicated with Heart Failure and Its Effect on Myocardium Enzymes

作　　者：黄妮娜[1] 高晓鹏[2] 章玉丹 刘科贝[1] 陈镜[1] HUANG Ni-na GAO Xiao-peng ZHANG Yu-dan LIU Ke-bei CHEN Jin(Emergency Department, Xi＇an Children＇s Hospital, Xi＇an, Shaanxi, 710003, China Central Laboratory, Xi＇an Children＇s Hospital, Xi＇an, Shaanxi, 710003, China)

机构地区：[1]西安市儿童医院急诊科,陕西西安710003 [2]西安市儿童医院中心实验室,陕西西安710003

出　　处：《现代生物医学进展》2017年第12期2302-2305,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨多巴胺联合酚妥拉明治疗小儿重症肺炎合并心力衰竭疗效及心肌酶学变化情况。方法:选择2014年10月至2015年3月之间于我院进行治疗的重症肺炎合并心力衰竭患儿185例作为研究对象随机分组。对照组92例患儿给予常规综合治疗,观察组93例患儿在此基础上给予多巴胺联合酚妥拉明治疗。比较两组患儿临床疗效、症状改善时间、治疗前后生命体征及心肌酶学指标变化情况以及不良反应发生情况。结果:观察组显效率及总有效率显著高于对照组,症状改善时间显著短于对照组,差异有统计学意义(P<0.05)。治疗前两组患儿生命体征及心肌酶学各项指标均无显著差异(P>0.05),治疗后两组患儿呼吸频率(HR)、心率(RR)显著下降,血氧饱和度(SpO_2)显著升高,心肌酶学各项指标均显著下降,差异较治疗前均有统计学意义(P<0.05)。组间比较,观察组患儿治疗后生命体征及心肌酶学各指标均明显优于对照组,差异有统计学意义(P<0.05)。两组患儿不良反应发生率无明显差异(P>0.05)。结论:多巴酚联合酚妥拉明治疗小儿重症肺炎合并心力衰竭具有良好的临床疗效及安全性,利于患儿临床症状及心肌损伤的恢复,值得临床推广应用。Objective： To explore the clinical efficacy of dopamine combined with phentolamine in treatment of children with serious pneumonia complicated with heart failure and its effect on myocardium enzymes. Methods： 185 children with serious pneumonia complicated with heart failure accepted in our hospital from October 2014 to March 2015 were selected and randomly divided into two groups. 92 patients in control group were given normal combined treatment, and 93 patients in observation group were given dopamine combined with phentolamine additionally. Then the clinical efficacy, the time of symptoms improved, the change of vital signs and myocardium enzymes levels before and after treatment and adverse reactions of two groups were detected and compared. Results： The significant efficiency and total efficiency of observation group were higher than that of control group, the time of symptoms improved of observation group was shorter than that of control group with statistically significance （P〈0.05）. The vital signs and myocardium enzymes levels before treatment of two groups had no statistically significance （P〉0.05）. HR, RR were decreased, SpO2 was increased and myocardium enzymes levels were all decreased after treatment, the indexes of observation group were all better than those of control group with statistically significance （P〈0.05）. The incidence of adverse reactions of two groups had no statistically difference （P〉0.05）. Conclusions： Dopamine combined with phentolamine has good efficacy and safety in treatment of children with serious pneumonia complicated with heart failure, which is beneficial to the improvement of clinical symptoms and myocardial injury, worthy of clinical application.

关 键 词：小儿肺炎合并心力衰竭 多巴胺 酚妥拉明 心肌酶学 

分 类 号：R725.6[医药卫生—儿科] R541.61[医药卫生—临床医学]