硒对癌症的预防和临床问题的研究现状  

Clinical Issues and Implications Studies of Selenium in Cancer Prevention

作　　者：吴英德[1] 吴开国[2] 

机构地区：[1]广西医科大学附属肿瘤医院,广西南宁530021 [2]广西医科大学

出　　处：《广东微量元素科学》2002年第6期18-24,共7页Trace Elements Science

摘　　要：从流行病学、实验室和临床等的研究均表明微量元素硒具有化学防癌的潜力 ,特别是近来富硒酵母应用于肺癌、肠癌、前列腺癌和肝癌等临床干预试验 ,表现出硒具有强大的保护作用。本文着重论述了硒化合物发展成为化学防癌药物的作用机制问题 ,这些机制表现在硒具有抗致癌的生物活性。还讨论了对硒的化学预防试验人群的选择 ,硒的干预试验 ,临床应用结果和安全范围的指标等问题。The trace element selenium(Se)has been shown to have chemopreventive potential by a converging body of evidence from epidemiological,experimental and clinical studies.In particular,the results of recent clinical intervention trials have shown strong protective effects of Se in the form of Se enriched yeast for cancers of the lung,colon,prostate,and liver.The present review highlights the key issues surrounding the development of Se compounds as chemopreventive agents in the context of the mechanisms that appear to account for their anticarcinogenic activities.This review also discusses appropriate target population markers of biology,clinical effective in treatment of Se,selenium safety and tolerated dose ranging for cancer preventive efficacy.

关 键 词：硒 化学预防 肿瘤预防 临床应用 安全性 耐受剂量 癌症 

分 类 号：R730.1[医药卫生—肿瘤] R613.52[医药卫生—临床医学]