筋骨草属植物中二萜类成分的化学及药理活性研究进展  

Progress on Diterpenoids and Their Biological activities of the Genus Ajuga

作　　者：陈昊[1] 梁敬钰[1] 孙建博[1] 陈莉[1] 

机构地区：[1]中国药科大学天然药化教研室,南京210009

出　　处：《海峡药学》2017年第3期1-10,共10页Strait Pharmaceutical Journal

基　　金："国家十一五重大新药创制"重大专项基金(2011ZX09307-002-02)

摘　　要：唇形科筋骨草属植物的主要成分是新克罗烷型和松香烷型二萜,新克罗烷型二萜具有C-4,C-9位侧链取代基类型多变的结构特点,松香烷型二萜结构中多存在一个或多个酚羟基,筋骨草属植物的二萜类成分具有抗炎,抗菌,抗肿瘤,降压以及昆虫拒食等广泛药理活性。本文对筋骨草属植物的二萜类成分及其药理活性进行综述,为该类化合物的后续研究提供参考。Therearemany important medicinal plants in Genus Ajuga （ Labiatae. ）, and their medicinal potential is due to the presense of various pharmacologically active compounds, especially affluent neo-clerodane and abietane diterpenoids with activities such as antifeedant, anti-inflammatory, antibacterial, antitumor as well as antihypertens- ive. The neo-clerodane diterpenoid＇s structure characteristics are the multilingualsubstitutes at positions4 and 9. In addition, phenolic hydroxyl groups always exist was to gather information about diterpenoids in twenty years for further study and ploit. in the structure of abietane diterpenoids. The aim of this review article Ajuga and their biological activities which has been published nearly

关 键 词：筋骨草属 二萜 结构特点 药理活性 

分 类 号：R969[医药卫生—药理学]